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85 条记录 (耗时 0.021 秒)

    Iodinated aromatic compounds
    1.
    发明授权
    Iodinated aromatic compounds 失效
    碘化芳族化合物

    公开(公告)号：US5384107A

    公开(公告)日：1995-01-24

    申请号：US285595

    申请日：1994-08-03

    申请人： Baldev Singh ,  Edward R. Bacon ,  Carl R. Illig

    发明人： Baldev Singh ,  Edward R. Bacon ,  Carl R. Illig

    IPC分类号： C07C57/52 ,  A61K49/04 ,  C07C233/54 ,  C07C233/88 ,  C07C255/55

    CPC分类号： A61K49/0433 ,  C07C233/54 ,  C07C233/88 ,  C07C255/55

    摘要： Compounds having the structure ##STR1## wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 6;R.sup.1 and R.sup.2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy;R.sup.3 and R.sup.4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino;Q represents the atoms necessary to complete a carbocyclic or heterocyclic unsaturated mono- or bicyclic aromatic ring; andR.sup.5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, amino, acylamino, alkoxyalkyl, fluoroalkyl, acetamidoalkyl, COO-alkyl, cyano, carboxamido, sulfonate, sulfonamido, ureido, or carbamyl are useful as contrast agents in x-ray imaging compositions and methods.

    摘要翻译： 具有结构的化合物，其中（Z-COO是碘化芳族酸的残基; n是0至6的整数; R 1和R 2独立地是H，烷基，氟代烷基，环烷基，芳基，芳烷基，烷氧基或芳氧基 R 3和R 4独立地为H，烷基，氟代烷基，环烷基，芳基，芳烷基，烷氧基，芳氧基，卤素，羟基或酰基氨基; Q表示完成碳环或杂环不饱和单环或双环芳环所必需的原子; H，烷基，环烷基，芳基，芳烷基，烷氧基，芳氧基，卤素，羟基，氨基，酰氨基，烷氧基烷基，氟代烷基，乙酰氨基烷基，COO-烷基，氰基，甲酰氨基，磺酸酯，亚磺酰氨基，脲基或氨基甲酰基可用作对比剂 x射线成像组合物和方法。

    Compositions of iodophenoxy alkylene ethers for visualization of the gastrointestinal tract
    4.
    发明授权
    Compositions of iodophenoxy alkylene ethers for visualization of the gastrointestinal tract 失效
    用于可视化胃肠道的碘苯氧基亚烷基醚的组合物

    公开(公告)号：US5348727A

    公开(公告)日：1994-09-20

    申请号：US29485

    申请日：1993-03-11

    申请人： Edward R. Bacon ,  Carl R. Illig ,  Thomas J. Caulfield ,  Brent D. Douty ,  Kurt A. Josef

    发明人： Edward R. Bacon ,  Carl R. Illig ,  Thomas J. Caulfield ,  Brent D. Douty ,  Kurt A. Josef

    IPC分类号： A61K49/04 ,  C07C43/225 ,  C07C43/23 ,  C07C69/92 ,  C07C255/54 ,  A61B5/055 ,  A61K31/075 ,  C07C41/00

    CPC分类号： A61K49/0404 ,  A61K49/04 ,  A61K49/0409 ,  A61K49/0461 ,  C07C43/225

    摘要： A compound of the formula: ##STR1## wherein Z.dbd.H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, wherein thealkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R.dbd.C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl; each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p -(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C-Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H, or lower-alkyl, optionally substituted with halo;x is 1-4;n is [1-5]1-4;m is 1-15;p is 1-20; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, these compounds are useful as X-ray contrast agents or aryl-lower alkyl.

    摘要翻译： 其中Z = H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，烷氧基羰基，氰基，其中烷基和环烷基可以被卤素或卤代低级烷基取代; R = C 1 -C 25烷基，环烷基，或低级烷基; 羟基，羧基，低级烷氧基羰基或低级烷氧基 - 羰基氧基（CR 1 R 2）p - （CR 3 = CR 4）m Q或任选被卤素，氟 - 低级 - 烷基，芳基， （CR1R2）pC 3BOND CQ; R 1，R 2，R 3和R 4独立地为H或被卤素取代的低级烷基; x为1-4; n是[1-5] 1-4; m为1-15; p是1-20; Q为H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基，这些化合物可用作X射线造影剂或芳基 - 低级烷基。

    Nanoparticulate diagnostic diatrizoxy ester X-ray contrast agents for blood pool and lymphatic system imaging
    7.
    发明授权
    Nanoparticulate diagnostic diatrizoxy ester X-ray contrast agents for blood pool and lymphatic system imaging 失效
    纳米颗粒诊断二硫唑酯X射线造影剂用于血液池和淋巴系统成像

    公开(公告)号：US5525328A

    公开(公告)日：1996-06-11

    申请号：US265550

    申请日：1994-06-24

    申请人： Edward R. Bacon ,  Carl R. Illig ,  Irennegbe K. Osifo ,  Thomas S. Caulfield

    发明人： Edward R. Bacon ,  Carl R. Illig ,  Irennegbe K. Osifo ,  Thomas S. Caulfield

    IPC分类号： A61K49/04 ,  C07C233/54 ,  C07C229/60

    CPC分类号： B82Y5/00 ,  A61K49/0485

    摘要： This invention relates to methods of x-ray diagnostic imaging the blood pool and/or lymph system of a mammal comprising administering a contrast effective amount of a particulate iodinated aroyloxy ester contrast agent having the structure: ##STR1## wherein n is an integer from 3 to 20; R.sup.1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl;R.sup.2, R.sup.3 and R.sup.4 are independently H, alkyl, fluoroalkyl, alkoxy, aryloxy, halogen, hydroxy, acylamino, acetamidoalkyl, --COO-alkyl, --COO-aryl, --COO-aralkyl, cyano, sulfonyl, carboxamido or sulfonamido;R.sup.5 is H, alkyl, fluoroalkyl, halogen, hydroxy, acylamino, acetamidoalkyl, cyano, sulfonyl, carboxamido or sulfonamido;R.sup.6 and R.sup.7 are independently alkyl, cycloalkyl, aryl or aralkyl; andR.sup.8 and R.sup.9 are independently H or --COR.sup.6.This invention further relates to novel iodinated aroyloxy ester contrast agents having the above structure wherein n is an integer from 5 to 20, to x-ray contrast compositions comprising such agents, and to methods of x-ray diagnostic imaging utilizing such agents.

    摘要翻译： 本发明涉及对哺乳动物的血液池和/或淋巴系统进行x射线诊断成像的方法，该方法包括施用对比有效量的具有以下结构的颗粒状碘化芳氧基酯造影剂：具有以下结构的烷基，氟代烷基，环烷基，芳基 ，芳烷基，烷氧基烷基或乙酰氨基烷基; R 2，R 3和R 4独立地是H，烷基，氟烷基，烷氧基，芳氧基，卤素，羟基，酰氨基，乙酰氨基烷基，-COO-烷基，-COO-芳基，-COO-芳烷基，氰基，磺酰基，甲酰氨基或亚磺酰氨基; R5是H，烷基，氟烷基，卤素，羟基，酰氨基，乙酰胺基烷基，氰基，磺酰基，甲酰胺基或亚磺酰氨基; R6和R7独立地是烷基，环烷基，芳基或芳烷基; 并且R 8和R 9独立地为H或-COR 6。 本发明还涉及具有上述结构的具有上述结构的新型碘化芳酰氧基酯造影剂，其中n为5-20的整数，以及包含这些试剂的x射线对比剂组合物，以及利用这些试剂的X射线诊断成像方法。

    Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastrointestinal tract
    9.
    发明授权
    Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastrointestinal tract 失效
    碘苯基酯和碘苯基磺酸盐在成膜材料中用于胃肠道可视化的组合物

    公开(公告)号：US5372800A

    公开(公告)日：1994-12-13

    申请号：US192234

    申请日：1994-02-04

    申请人： Edward R. Bacon ,  Sol J. Daum ,  Kimberly G. Estep ,  Kurt A. Josef ,  Brent D. Douty ,  Carl R. Illig

    发明人： Edward R. Bacon ,  Sol J. Daum ,  Kimberly G. Estep ,  Kurt A. Josef ,  Brent D. Douty ,  Carl R. Illig

    IPC分类号： A61K9/107 ,  A61K47/02 ,  A61K47/36 ,  A61K47/38 ,  A61K49/04 ,  C07C69/63

    CPC分类号： A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract whereinX= ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy,n is 1-5;y is 0-4; andw is 1-4.

    摘要翻译： 公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含能够在胃肠道上形成涂层的聚合物材料和具有式“IMAGE”的X射线产生剂及其用于诊断放射学的方法 的胃肠道，其中X = Z，H =卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; R = C 1 -C 25烷基，环烷基，芳基或卤代低级烷基，任选被卤素，氟代低级烷基，低级烷氧基，羟基，羧基或低级烷氧基羰基，低级烯基，低级炔基，低级 - 亚烷基或低级 - 烷氧基 - 羰氧基，n为1-5; y为0-4; w为1-4。

    Compositions of alkylbenzenes in film-forming materials for visualization of the gastrointestinal tract
    10.
    发明授权
    Compositions of alkylbenzenes in film-forming materials for visualization of the gastrointestinal tract 失效
    用于胃肠道可视化的成膜材料中烷基苯的组成

    公开(公告)号：US5334370A

    公开(公告)日：1994-08-02

    申请号：US13459

    申请日：1993-02-04

    申请人： Kurt A. Josef ,  Edward R. Bacon ,  Kimberly G. Estep ,  Carl R. Illig ,  Brent D. Douty

    发明人： Kurt A. Josef ,  Edward R. Bacon ,  Kimberly G. Estep ,  Carl R. Illig ,  Brent D. Douty

    IPC分类号： A61K49/04 ,  C07C17/12 ,  C07C17/26 ,  C07C17/354 ,  C07C25/02 ,  C07C69/65 ,  C07C22/00 ,  C07C25/00 ,  C07C69/76

    CPC分类号： C07C17/12 ,  A61K49/0461 ,  C07C17/2635 ,  C07C17/354 ,  C07C25/02 ,  C07C69/65

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract whereinR=C.sub.1 -C.sub.25 alkyl, cycloalkyl, unsaturated allyl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H, lower-alkyl, optionally substituted with halo;n is 1-5;m is 1-5;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.

    摘要翻译： 公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含能够在胃肠道上形成涂层的聚合物材料和具有式“IMAGE”的X射线产生剂及其用于诊断放射学的方法 的胃肠道，其中R = C 1 -C 25烷基，环烷基，不饱和烯丙基或卤代低级烷基，任选被卤素，氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，羧基，低级 - 烷氧基羰基或低级 （CR 1 R 2）p - （CR 3 = CR 4）m Q或（CR 1 R 2）p C 3 B 3 CQ; R 1，R 2，R 3和R 4独立地为H，低级烷基，任选被卤素取代; n为1-5; m为1-5; p为1-10; 并且Q是H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。