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69 条记录 (耗时 0.03 秒)

    Polyiodinated aroyloxy esters
    6.
    发明授权
    Polyiodinated aroyloxy esters 失效
    多碘化芳酰基酯

    公开(公告)号：US5466433A

    公开(公告)日：1995-11-14

    申请号：US261794

    申请日：1994-06-20

    申请人： Edward R. Bacon ,  Sol J. Daum ,  Paul P. Spara

    发明人： Edward R. Bacon ,  Sol J. Daum ,  Paul P. Spara

    IPC分类号： C07C69/76 ,  A61K49/04 ,  C07C233/54 ,  C07C233/88 ,  C07C233/91

    CPC分类号： A61K49/0433 ,  C07C233/54 ,  C07C233/88 ,  C07C233/91

    摘要： Compounds having the structure ##STR1## wherein Z--COO).sub.m is the residue of a polyiodinated aromatic acid; m is 1, 2, 3 or 4;n is an integer from 1 to 20;R.sup.1 and R.sup.2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy;R.sup.3 and R.sup.4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino; andR.sup.5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl;are useful as contrast agents in x-ray imaging compositions and methods.

    摘要翻译： 具有结构的化合物，其中Z-COO）m是多元芳族酸的残基; m为1,2,3或4; n为1〜20的整数， R 1和R 2独立地为H，烷基，氟烷基，环烷基，芳基，芳烷基，烷氧基或芳氧基; R 3和R 4独立地为H，烷基，氟代烷基，环烷基，芳基，芳烷基，烷氧基，芳氧基，卤素，羟基或酰基氨基; R5是H，烷基，环烷基，芳基，芳烷基，烷氧基烷基或乙酰氨基烷基; 作为x射线成像组合物和方法中的造影剂是有用的。

    Iodinated aromatic compounds
    7.
    发明授权
    Iodinated aromatic compounds 失效
    碘化芳族化合物

    公开(公告)号：US5384107A

    公开(公告)日：1995-01-24

    申请号：US285595

    申请日：1994-08-03

    申请人： Baldev Singh ,  Edward R. Bacon ,  Carl R. Illig

    发明人： Baldev Singh ,  Edward R. Bacon ,  Carl R. Illig

    IPC分类号： C07C57/52 ,  A61K49/04 ,  C07C233/54 ,  C07C233/88 ,  C07C255/55

    CPC分类号： A61K49/0433 ,  C07C233/54 ,  C07C233/88 ,  C07C255/55

    摘要： Compounds having the structure ##STR1## wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 6;R.sup.1 and R.sup.2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy;R.sup.3 and R.sup.4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino;Q represents the atoms necessary to complete a carbocyclic or heterocyclic unsaturated mono- or bicyclic aromatic ring; andR.sup.5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, amino, acylamino, alkoxyalkyl, fluoroalkyl, acetamidoalkyl, COO-alkyl, cyano, carboxamido, sulfonate, sulfonamido, ureido, or carbamyl are useful as contrast agents in x-ray imaging compositions and methods.

    摘要翻译： 具有结构的化合物，其中（Z-COO是碘化芳族酸的残基; n是0至6的整数; R 1和R 2独立地是H，烷基，氟代烷基，环烷基，芳基，芳烷基，烷氧基或芳氧基 R 3和R 4独立地为H，烷基，氟代烷基，环烷基，芳基，芳烷基，烷氧基，芳氧基，卤素，羟基或酰基氨基; Q表示完成碳环或杂环不饱和单环或双环芳环所必需的原子; H，烷基，环烷基，芳基，芳烷基，烷氧基，芳氧基，卤素，羟基，氨基，酰氨基，烷氧基烷基，氟代烷基，乙酰氨基烷基，COO-烷基，氰基，甲酰氨基，磺酸酯，亚磺酰氨基，脲基或氨基甲酰基可用作对比剂 x射线成像组合物和方法。

    Iodinated wetting agents
    8.
    发明授权
    Iodinated wetting agents 失效
    碘化润湿剂

    公开(公告)号：US5346688A

    公开(公告)日：1994-09-13

    申请号：US991640

    申请日：1992-12-16

    申请人： Edward R. Bacon ,  Gregory L. McIntire

    发明人： Edward R. Bacon ,  Gregory L. McIntire

    IPC分类号： A61K49/04 ,  C07C53/126 ,  C07C63/06 ,  C07C233/54

    CPC分类号： C07C233/54

    摘要： Compounds having the structure ##STR1## wherein (Z)--COO is the residue of an iodinated aromatic acid; M is H, a cation, --CH.sub.2 CH.sub.2 O--.sub.m H, and --CH.sub.2 CH(OH)O--.sub.p H;m is an integer from 1 to 150;p is an integer from 1 to 50; andL is one or more divalent linking groups selected from alkylene, cycloalkylene, arylene, arylenealkylene, and alkylenearylene are particularly useful as wetting agents in x-ray imaging compositions.

    摘要翻译： 具有结构（Z）COOLCO2M的化合物，其中（Z）-COO是碘化芳族酸的残基; M是H，阳离子，-CH2CH2O-mH和-CH2CH（OH）O-pH; m为1〜150的整数; p是1至50的整数; L是选自亚烷基，亚环烷基，亚芳基，亚芳基亚烷基和亚烷基亚芳基中的一个或多个二价连接基团，其特别用作x射线成像组合物中的润湿剂。

    Imidazopyridines, their preparation and use
    9.
    发明授权
    Imidazopyridines, their preparation and use 失效
    咪唑并吡啶，其制备和用途

    公开(公告)号：US4963561A

    公开(公告)日：1990-10-16

    申请号：US486637

    申请日：1990-02-28

    申请人： George Y. Lesher ,  Edward R. Bacon ,  Baldev Singh ,  Gee-Hong Kuo

    发明人： George Y. Lesher ,  Edward R. Bacon ,  Baldev Singh ,  Gee-Hong Kuo

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： Novel 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula ##STR1## where R.sub.1 and R.sub.3 are hydrogen or lower-alkyl, R.sub.5 is lower-alkyl or fluorinated lower-alkyl, and Ar is 4- or 3-pyridinyl, or phenyl or substituted phenyl.

    摘要翻译： 具有6位芳基或杂芳基的新颖的1,3-二氢-2H-咪唑并[4,5-b]吡啶-2-酮可用作磷酸二酯酶抑制剂，通过2-氨基-5- （芳基或杂芳基）吡啶-3-羧酸与二苯基磷酰基叠氮化物。 这些化合物具有式“IMAGE”，其中R 1和R 3是氢或低级烷基，R 5是低级烷基或氟代低级烷基，Ar是4-或3-吡啶基，或苯基或取代的苯基。