发明授权
US5405946A Recombinant protein S variants deficient in C4BP binding activity,
compositions and therapeutic methods
失效
缺乏C4BP结合活性的重组蛋白S变体，组合物和治疗方法
- 专利标题： Recombinant protein S variants deficient in C4BP binding activity, compositions and therapeutic methods
- 专利标题（中）： 缺乏C4BP结合活性的重组蛋白S变体，组合物和治疗方法
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申请号： US985691申请日： 1992-12-02
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公开(公告)号： US5405946A公开(公告)日： 1995-04-11
- 发明人: John H. Griffin , Bonno N. Bouma , Rogier Bertina
- 申请人： John H. Griffin , Bonno N. Bouma , Rogier Bertina
- 申请人地址： CA La Jolla
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： CA La Jolla
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/475 ; C12N15/12 ; C07K13/00
摘要：
The present invention describes a variant protein S protein that is substantially homologous in amino acid residue sequence to wild-type mature human protein S, which has in vitro anticoagulant activity and has a reduced ability to bind C4b binding protein (C4BP), compositions containing the variant protein S, and recombinant DNA vectors for expressing the variant protein. Also disclosed are therapeutic methods of using variant protein S for inhibiting thrombosis, inflammation and the like conditions ameliorated by protein S.
公开/授权文献
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