公开(公告)号：US5405946A

公开(公告)日：1995-04-11

申请号：US985691

申请日：1992-12-02

申请人： John H. Griffin ,  Bonno N. Bouma ,  Rogier Bertina

发明人： John H. Griffin ,  Bonno N. Bouma ,  Rogier Bertina

IPC分类号： A61K38/00 ,  C07K14/475 ,  C12N15/12 ,  C07K13/00

CPC分类号： C07K14/475 ,  A61K38/00 ,  Y10S530/83

摘要： The present invention describes a variant protein S protein that is substantially homologous in amino acid residue sequence to wild-type mature human protein S, which has in vitro anticoagulant activity and has a reduced ability to bind C4b binding protein (C4BP), compositions containing the variant protein S, and recombinant DNA vectors for expressing the variant protein. Also disclosed are therapeutic methods of using variant protein S for inhibiting thrombosis, inflammation and the like conditions ameliorated by protein S.

摘要翻译： 本发明描述了在具有体外抗凝活性并具有降低的结合C4b结合蛋白（C4BP）的能力的野生型成熟人蛋白S的氨基酸残基序列中基本上同源的变体蛋白S蛋白，其含有 变体蛋白S和用于表达变体蛋白质的重组DNA载体。 还公开了使用变体蛋白S抑制蛋白质S改善的血栓形成，炎症等状况的治疗方法。