发明授权
US5430139A 2'-alkylidenepyrimidine nucleoside derivatives, process for production
thereof, and uses thereof
失效
2'-亚基亚嘧啶核苷衍生物，其制备方法及其用途
- 专利标题： 2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof
- 专利标题（中）： 2'-亚基亚嘧啶核苷衍生物，其制备方法及其用途
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申请号： US125839申请日： 1993-09-24
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公开(公告)号： US5430139A公开(公告)日： 1995-07-04
- 发明人: Akira Matsuda , Tohru Ueda , Kenji Takenuki , Haruhiko Machida
- 申请人： Akira Matsuda , Tohru Ueda , Kenji Takenuki , Haruhiko Machida
- 申请人地址： JPX Chiba
- 专利权人： Yamasa Shoyu Kabushiki Kaisha
- 当前专利权人： Yamasa Shoyu Kabushiki Kaisha
- 当前专利权人地址： JPX Chiba
- 优先权： JPX62-65405 19870319; JPX63-20032 19880130
- 主分类号： C07H19/06
- IPC分类号： C07H19/06
摘要：
Disclosed are novel 2'-alkylidenepyrimidine nucleoside derivatives represented by formula [I]: ##STR1## R.sup.1 is an amino group or a hydroxy group, R.sup.2 is a hydrogen atom, a halogen atom or a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group, and R.sup.4 is a hydrogen atom or a phosphate residue, or salts thereof. These novel compounds can be produced from uridine or cytidine derivatives by alkylidenating the 2'-position in the sugar moiety thereof with Wittig's reagent. Furthermore, the compounds have remarkable antiviral activities and therefore can provide novel antiviral agents.
公开/授权文献
- US6147750A Determination of gloss quality 公开/授权日：2000-11-14
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