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49 条记录 (耗时 0.026 秒)

    2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof
    1.
    发明授权
    2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof 失效
    2'-亚基亚嘧啶核苷衍生物，其制备方法及其用途

    公开(公告)号：US5430139A

    公开(公告)日：1995-07-04

    申请号：US125839

    申请日：1993-09-24

    申请人： Akira Matsuda ,  Tohru Ueda ,  Kenji Takenuki ,  Haruhiko Machida

    发明人： Akira Matsuda ,  Tohru Ueda ,  Kenji Takenuki ,  Haruhiko Machida

    IPC分类号： C07H19/06

    CPC分类号： C07H19/06 ,  Y02P20/55

    摘要： Disclosed are novel 2'-alkylidenepyrimidine nucleoside derivatives represented by formula [I]: ##STR1## R.sup.1 is an amino group or a hydroxy group, R.sup.2 is a hydrogen atom, a halogen atom or a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group, and R.sup.4 is a hydrogen atom or a phosphate residue, or salts thereof. These novel compounds can be produced from uridine or cytidine derivatives by alkylidenating the 2'-position in the sugar moiety thereof with Wittig's reagent. Furthermore, the compounds have remarkable antiviral activities and therefore can provide novel antiviral agents.

    摘要翻译： 公开了由式[I]表示的新的2'-亚烷基嘧啶核苷衍生物：其中R 1为氨基或羟基，R 2为氢原子，卤素原子或低级烷基，R 3为 氢原子或低级烷基，R4为氢原子或磷酸酯残基，或其盐。 这些新化合物可以由尿苷或胞苷衍生物通过用Wittig's试剂将其部分上的2'-位进行亚烷基化来制备。 此外，化合物具有显着的抗病毒活性，因此可以提供新的抗病毒剂。

    Anxiolytic drugs
    2.
    发明授权
    Anxiolytic drugs 失效
    溶血药

    公开(公告)号：US5334593A

    公开(公告)日：1994-08-02

    申请号：US867712

    申请日：1992-07-09

    申请人： Masahiro Imaizumi ,  Shinji Sakata

    发明人： Masahiro Imaizumi ,  Shinji Sakata

    IPC分类号： A61K31/505 ,  C07D239/54 ,  C07D239/553

    CPC分类号： C07D239/553 ,  A61K31/505

    摘要： The present invention relates to an anxiolytic drug comprising as an active ingredient a 1-amino-5-halogenouracil represented by formula [I]: ##STR1## wherein X represents a halogen atom, or pharmaceutically acceptable salt thereof.

    摘要翻译： PCT No.PCT / JP91 / 00015 Sec。 371日期：1992年7月9日 102（e）日期1992年7月9日PCT 1991年1月11日PCT PCT。 出版物WO91 / 10432 1991年7月25日。本发明涉及包含式[I]所示的1-氨基-5-卤代尿嘧啶作为活性成分的抗焦虑药物或其药学上可接受的盐。

    2'-alkylidenepyrimidine nucleoside compounds and a process for production of same
    3.
    发明授权
    2'-alkylidenepyrimidine nucleoside compounds and a process for production of same 失效
    2'-亚苄基嘧啶核苷化合物及其制备方法

    公开(公告)号：US5300636A

    公开(公告)日：1994-04-05

    申请号：US721828

    申请日：1991-06-26

    申请人： Akira Matsuda ,  Tohru Ueda ,  Kenji Takenuki ,  Haruhiko Machida

    发明人： Akira Matsuda ,  Tohru Ueda ,  Kenji Takenuki ,  Haruhiko Machida

    IPC分类号： C07H19/06

    CPC分类号： C07H19/06 ,  Y02P20/55

    摘要： Disclosed are novel 2'-alkylidenepyrimidine nucleoside derivatives represented by formula [I]: ##STR1## wherein R.sup.1 is an amino group or a hydroxy group, R.sup.2 is a hydrogen atom, a halogen atom or a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group, and R.sup.4 is a hydrogen atom or a phosphate residue, or salts thereof.These novel compounds can be produced from uridine or cytidine derivatives by alkylidenating the 2'-position in the sugar moiety thereof with Wittig's reagent.Furthermore, the compounds have remarkable antiviral activities and therefore can provide novel antiviral agents.

    摘要翻译： 公开了由式[I]表示的新颖的2'-亚烷基嘧啶核苷衍生物：其中R1是氨基或羟基，R2是氢原子，卤素原子或低级烷基，R3是 氢原子或低级烷基，R 4为氢原子或磷酸酯残基，或其盐。 这些新化合物可以由尿苷或胞苷衍生物通过用Wittig's试剂将其部分上的2'-位进行亚烷基化来制备。 此外，化合物具有显着的抗病毒活性，因此可以提供新的抗病毒剂。

    Process for producing ribavirin
    6.
    发明授权
    Process for producing ribavirin 失效
    生产利巴韦林的方法

    公开(公告)号：US4614719A

    公开(公告)日：1986-09-30

    申请号：US489409

    申请日：1983-04-26

    申请人： Tetsuro Fujishima ,  Yoshiomi Yamamoto

    发明人： Tetsuro Fujishima ,  Yoshiomi Yamamoto

    IPC分类号： C12P19/28 ,  C07H19/056 ,  C12P19/38

    CPC分类号： C12P19/38 ,  C07H19/056 ,  Y10S435/84

    摘要： There is disclosed a process for producing ribavirin from 1,2,4-triazole-carboxamide and a ribose donor by the enzymatic action of a microorganism belonging to specific genera, e.g. Brevebacterium. The specific feature of the invention is, above all, utilization of said microorganism under non-proliferatating conditions.

    摘要翻译： 公开了一种由1,2,4-三唑 - 甲酰胺和核糖供体产生利巴韦林的方法，该方法通过属于特定属的微生物的酶促作用，例如， 短杆菌。 本发明的具体特征首先是在非增殖条件下利用所述微生物。

    Process for producing 3-deoxyguanosine
    7.
    发明授权
    Process for producing 3-deoxyguanosine 失效
    3-脱氧鸟苷的制备方法

    公开(公告)号：US4594320A

    公开(公告)日：1986-06-10

    申请号：US479980

    申请日：1983-03-29

    申请人： Tetsuro Fujishima

    发明人： Tetsuro Fujishima

    IPC分类号： C12P19/40 ,  C12R1/01 ,  C12R1/265 ,  C12R1/44 ,  C12R1/445 ,  C12R1/45 ,  C12R1/64 ,  C12N9/12 ,  C12P19/30 ,  C12P19/38

    CPC分类号： C12P19/40

    摘要： Glycosylation or transglycosylation of a specified guanine derivative, namely 9-substituted or non-substituted guanine of formula [I] with a 3-deoxyribose donor such as 3'-deoxyadenosine in the presence of a nucleoside phosphorylase source such as of microorganism origin is disclosed. The nucleoside phosphorylase source is specified.

    摘要翻译： 公开了在诸如微生物来源的核苷磷酸化酶源的存在下，特定的鸟嘌呤衍生物，即式[I]的9-取代或未取代的鸟嘌呤与3-脱氧核糖供体如3'-脱氧腺苷的糖基化或转糖基化 。 指定核苷磷酸化酶源。

    Determination of adenosine by immunoassay involving acylation of the adenosine
    8.
    发明授权
    Determination of adenosine by immunoassay involving acylation of the adenosine 失效
    通过涉及腺苷酰化的免疫测定法测定腺苷

    公开(公告)号：US4478934A

    公开(公告)日：1984-10-23

    申请号：US396863

    申请日：1982-07-09

    申请人： Tomokazu Sato ,  Michio Ui

    发明人： Tomokazu Sato ,  Michio Ui

    IPC分类号： G01N33/53 ,  G01N33/537 ,  G01N33/54

    CPC分类号： G01N33/537 ,  G01N33/5308 ,  Y10S436/815

    摘要： A method of quantative determination of adenosine by means, of competitive immunoassay based on a competitive antigen-antibody reaction. In the competitive antigen-antibody reaction, an antibody is used which is obtained from an animal which has been immunized by introduction thereto of an antigen which comprises a carrier protein bonded with 2'- and 3'-hydroxyls of the adenosine through dicarboxylic acid residues, and a labelled adenosine and 2',3'-diacyladenosine which has been produced by acylation of adenosine in the sample to be assayed or in a standard solution are caused to undergo competitive reaction for the antibody whereby it has been made possible to determine adenosine quantitatively in high sensitivity and in high accuracy.

    摘要翻译： 基于竞争性抗原 - 抗体反应的竞争性免疫测定方法，定量测定腺苷的方法。 在竞争性抗原 - 抗体反应中，使用从通过引入抗原免疫的动物获得的抗体，所述抗原包含通过二羧酸残基与腺苷的2'-和3'-羟基键合的载体蛋白 并且通过在待测样品中或在标准溶液中酰化腺苷产生的标记的腺苷和2'，3'-二酰基腺苷被引起进行抗体的竞争反应，由此已经可以确定腺苷 定量地在高灵敏度和高精度。

    S-Adenosyl-L-methionine compositions and production thereof
    10.
    发明授权
    S-Adenosyl-L-methionine compositions and production thereof 失效
    S-腺苷-L-甲硫氨酸组成及其生产

    公开(公告)号：US4242505A

    公开(公告)日：1980-12-30

    申请号：US929294

    申请日：1978-07-28

    申请人： Toshihisa Kawahara ,  Goro Motoki

    发明人： Toshihisa Kawahara ,  Goro Motoki

    IPC分类号： C07H19/16 ,  G11B27/00

    CPC分类号： C07H19/16 ,  G11B27/00 ,  Y10S514/824

    摘要： S-adenosyl-L-methionine compositions stabilized against decomposition of S-adenosyl-L-methionine comprising S-adenosyl-L-methionine, a sulfuric acid equivalent and a nucleoside sulfate, which are produced from a solution comprising the three essential components in an aqueous solvent by, for example, adding thereto a water-miscible organic solvent thereby to precipitate the composition (process A) and/or by evaporating the aqueous solvent off the solution (process B).

    摘要翻译： S-腺苷-L-甲硫氨酸组合物，其稳定化为包含S-腺苷-L-甲硫氨酸，硫酸当量和核苷硫酸盐的S-腺苷-L-甲硫氨酸的分解，其由包含三 水溶剂，例如向其中加入水混溶性有机溶剂，由此使组合物沉淀（方法A）和/或通过将溶剂蒸发掉溶液（方法B）。