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33 条记录 (耗时 0.018 秒)

    2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof
    1.
    发明授权
    2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof 失效
    2'-亚基亚嘧啶核苷衍生物，其制备方法及其用途

    公开(公告)号：US5047520A

    公开(公告)日：1991-09-10

    申请号：US295948

    申请日：1988-11-18

    申请人： Akira Matsuda ,  Tohru Ueda ,  Kenji Takenuki ,  Haruhiko Machida

    发明人： Akira Matsuda ,  Tohru Ueda ,  Kenji Takenuki ,  Haruhiko Machida

    IPC分类号： C07H19/06

    CPC分类号： C07H19/06 ,  Y02P20/55

    摘要： Disclosed are novel 2'-alkylidenepyrimidine nucleoside derivatives represented by formula [I]: ##STR1## wherein R.sup.1 is an amino gorup or a hydroxy group, R.sup.2 is a hydrogen atom, a halogen atom or a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group, and R.sup.4 is a hydrogen atom or a phosphate residue, or salts thereof.These novel compounds can be produced from uridine or cytidine derivatives by alkylidenating the 2'-position in the sugar moiety thereof with Wittig's reagent.Furthermore, the compounds have remarkable antiviral activities and therefore can provide novel antiviral agents.

    摘要翻译： PCT No.PCT / JP88 / 00278 Sec。 371日期1988年11月18日 102（e）1988年11月18日日期PCT提交1988年3月17日PCT公布。 出版物WO88 / 07049 日期：1988年9月22日。公开的是由式[I]表示的新颖的2'-亚烷基嘧啶核苷衍生物：其中R1是氨基酸或羟基，R2是氢原子，卤素原子或 低级烷基，R3为氢原子或低级烷基，R4为氢原子或磷酸酯基，或其盐。 这些新化合物可以由尿苷或胞苷衍生物通过用Wittig's试剂将其部分上的2'-位进行亚烷基化来制备。 此外，化合物具有显着的抗病毒活性，因此可以提供新的抗病毒剂。

    2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof
    2.
    发明授权
    2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof 失效
    2'-亚基亚嘧啶核苷衍生物，其制备方法及其用途

    公开(公告)号：US5430139A

    公开(公告)日：1995-07-04

    申请号：US125839

    申请日：1993-09-24

    申请人： Akira Matsuda ,  Tohru Ueda ,  Kenji Takenuki ,  Haruhiko Machida

    发明人： Akira Matsuda ,  Tohru Ueda ,  Kenji Takenuki ,  Haruhiko Machida

    IPC分类号： C07H19/06

    CPC分类号： C07H19/06 ,  Y02P20/55

    摘要： Disclosed are novel 2'-alkylidenepyrimidine nucleoside derivatives represented by formula [I]: ##STR1## R.sup.1 is an amino group or a hydroxy group, R.sup.2 is a hydrogen atom, a halogen atom or a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group, and R.sup.4 is a hydrogen atom or a phosphate residue, or salts thereof. These novel compounds can be produced from uridine or cytidine derivatives by alkylidenating the 2'-position in the sugar moiety thereof with Wittig's reagent. Furthermore, the compounds have remarkable antiviral activities and therefore can provide novel antiviral agents.

    摘要翻译： 公开了由式[I]表示的新的2'-亚烷基嘧啶核苷衍生物：其中R 1为氨基或羟基，R 2为氢原子，卤素原子或低级烷基，R 3为 氢原子或低级烷基，R4为氢原子或磷酸酯残基，或其盐。 这些新化合物可以由尿苷或胞苷衍生物通过用Wittig's试剂将其部分上的2'-位进行亚烷基化来制备。 此外，化合物具有显着的抗病毒活性，因此可以提供新的抗病毒剂。

    2'-alkylidenepyrimidine nucleoside compounds and a process for production of same
    3.
    发明授权
    2'-alkylidenepyrimidine nucleoside compounds and a process for production of same 失效
    2'-亚苄基嘧啶核苷化合物及其制备方法

    公开(公告)号：US5300636A

    公开(公告)日：1994-04-05

    申请号：US721828

    申请日：1991-06-26

    申请人： Akira Matsuda ,  Tohru Ueda ,  Kenji Takenuki ,  Haruhiko Machida

    发明人： Akira Matsuda ,  Tohru Ueda ,  Kenji Takenuki ,  Haruhiko Machida

    IPC分类号： C07H19/06

    CPC分类号： C07H19/06 ,  Y02P20/55

    摘要： Disclosed are novel 2'-alkylidenepyrimidine nucleoside derivatives represented by formula [I]: ##STR1## wherein R.sup.1 is an amino group or a hydroxy group, R.sup.2 is a hydrogen atom, a halogen atom or a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group, and R.sup.4 is a hydrogen atom or a phosphate residue, or salts thereof.These novel compounds can be produced from uridine or cytidine derivatives by alkylidenating the 2'-position in the sugar moiety thereof with Wittig's reagent.Furthermore, the compounds have remarkable antiviral activities and therefore can provide novel antiviral agents.

    摘要翻译： 公开了由式[I]表示的新颖的2'-亚烷基嘧啶核苷衍生物：其中R1是氨基或羟基，R2是氢原子，卤素原子或低级烷基，R3是 氢原子或低级烷基，R 4为氢原子或磷酸酯残基，或其盐。 这些新化合物可以由尿苷或胞苷衍生物通过用Wittig's试剂将其部分上的2'-位进行亚烷基化来制备。 此外，化合物具有显着的抗病毒活性，因此可以提供新的抗病毒剂。

    2-alkynyladenosines as antihypertensive agents
    4.
    发明授权
    2-alkynyladenosines as antihypertensive agents 失效
    2-炔基腺苷作为抗高血压药

    公开(公告)号：US4956345A

    公开(公告)日：1990-09-11

    申请号：US282892

    申请日：1988-12-12

    申请人： Tadashi Miyasaka ,  Akira Matsuda ,  Toichi Abiru ,  Haruhiko Machida

    发明人： Tadashi Miyasaka ,  Akira Matsuda ,  Toichi Abiru ,  Haruhiko Machida

    IPC分类号： C07H19/167 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P9/12 ,  C07H19/067 ,  C07H19/16

    CPC分类号： C07H19/16

    摘要： A 2-alkynyladenosine represented by general formula [I]: ##STR1## wherein n is an integer of from 2 to 15, has been found to have excellent properties as an antihypertensive agent. On the basis of this finding, the present invention has provided an antihypertensive agent comprising an antihypertensive effective amount of a compound of the above formula [I] and a pharmaceutically acceptable carrier. The present invention also discloses a novel compound 2-alkynyladenosine of formula [I] shown above wherein n is 6 to 15.

    摘要翻译： 由通式[I]表示的2-炔基腺苷：其中n为2〜15的整数，已被发现具有作为抗高血压剂的优异的性质。 基于该发现，本发明提供了包含抗高血压有效量的上述式[I]的化合物和药学上可接受的载体的抗高血压药。 本发明还公开了上述式[I]的新化合物2-炔基腺苷，其中n为6至15。

    Injectable formulation of antibiotic and solution for intravenous administration thereof
    5.
    发明授权
    Injectable formulation of antibiotic and solution for intravenous administration thereof 有权
    用于静脉内给药的抗生素和溶液的注射制剂

    公开(公告)号：US07968588B2

    公开(公告)日：2011-06-28

    申请号：US12306663

    申请日：2007-06-28

    申请人： Hirofumi Nakajima ,  Haruhiko Machida

    发明人： Hirofumi Nakajima ,  Haruhiko Machida

    IPC分类号： A61K31/403 ,  A61P31/04

    CPC分类号： A61K9/0019 ,  A61K38/15 ,  A61K47/40

    摘要： A pharmaceutical composition for injection comprising a depsipeptide antibiotic, WAP-8294A2, as an active ingredient, which is stable and contains WAP-8294A2 in high concentrations is provided. This composition comprises WAP-8294A2 of the following structural formula (1) as an active ingredient and is characterized in that 2-hydroxypropyl-β-cyclodextrin or β-cyclodextrin is contained as a stabilizer or solubilizer and the pH of the composition is not adjusted. This composition is mixed with a pH-adjusting agent such as dextrose and with an infusion or diluent comprising a solution of disodium hydrogen phosphate, sodium dihydrogen phosphate, and sodium hydroxide at the time of use to prepare a solution for intravenous administration of WAP-8294A2.

    摘要翻译： 提供一种用于注射的药物组合物，其包含稳定并含有高浓度的WAP-8294A2作为活性成分的前肽类抗生素WAP-8294A2。 该组合物包含以下结构式（1）的WAP-8294A2作为活性成分，其特征在于含有2-羟丙基 - 环糊精或β-环糊精作为稳定剂或增溶剂，组合物的pH为 没有调整。 将该组合物与pH调节剂如葡萄糖和使用时的含有磷酸氢二钠，磷酸氢二钠和氢氧化钠的溶液的输液或稀释液混合，制备静脉内施用WAP-8294A2的溶液 。

    Cooking utensil
    6.
    发明授权
    Cooking utensil 失效
    炊具

    公开(公告)号：US4872445A

    公开(公告)日：1989-10-10

    申请号：US212781

    申请日：1988-06-29

    申请人： Hiroshi Kobayashi ,  Masae Kobayashi ,  Haruhiko Machida

    发明人： Hiroshi Kobayashi ,  Masae Kobayashi ,  Haruhiko Machida

    IPC分类号： A47J36/36 ,  A47J45/06

    CPC分类号： A47J45/06 ,  A47J36/36

    摘要： The present invention concerns an improved cooking utensil for keeping warm and cooking which comprises an inner vessel portion, an outer shell portion having an inside diameter larger than that of the inner vessel portion and a height as same as or longer than that of the inner vessel portion, said outer shell portion having a cylindrical shape, and a lid which closes an opening of the inner vessel portion, and a space portion being defined by said inner vessel portion and said outer shell portion, said inner vessel portion and said outer shell portion being combined or connected by a pair of hand grips.

    摘要翻译： 本发明涉及一种用于保温和烹饪的改进的炊具，其包括内容器部分，具有比内容器部分的内径大的内径的外壳部分和与内容器部分相同或更长的高度 所述外壳部分具有圆柱形形状，以及封闭所述内部容器部分的开口的盖子，以及由所述内部容器部分和所述外部壳体部分限定的空间部分，所述内部容器部分和所述外部壳体部分 通过一对手柄组合或连接。

    Method of measuring the amount of movement of an object having uniformly periodic structure
    7.
    发明授权
    Method of measuring the amount of movement of an object having uniformly periodic structure 失效
    测量具有均匀周期结构的物体的移动量的方法

    公开(公告)号：US4823001A

    公开(公告)日：1989-04-18

    申请号：US86942

    申请日：1987-08-17

    申请人： Hiroshi Kobayashi ,  Haruhiko Machida ,  Hideaki Ema ,  Jun Akedo

    发明人： Hiroshi Kobayashi ,  Haruhiko Machida ,  Hideaki Ema ,  Jun Akedo

    IPC分类号： G01B11/00 ,  G01D5/38 ,  G01D5/34

    CPC分类号： G01D5/38

    摘要： An object to be measured for the amount of movement thereof has a uniformly periodic structure. The object is illuminated with divergent light emitted from a coherent spot light source. By positionally adjusting the spot light source, the object, and a light sensor, an enlarged shadow-picture-like diffraction pattern of the uniformly periodic structure is generated at a position in which the light sensor is disposed. The shadow-picture-like diffraction pattern is moved when the object is moved across the divergent light from the spot light source. The amount of movement of the shadow-picture-like diffraction pattern is detected by the light sensor for thereby measuring the amount of movement of the object.

    摘要翻译： 要测量的物体的移动量具有均匀的周期性结构。 物体被从相干点光源发出的发散光照射。 通过位置调整聚光源，物体和光传感器，在布置有光传感器的位置处产生均匀周期性结构的放大的阴影图案衍射图案。 当物体移动穿过来自聚光源的发散光时，阴影图案样衍射图案被移动。 通过光传感器检测阴影图案衍射图案的移动量，从而测量物体的移动量。

    Converter
    10.
    发明授权
    Converter 失效
    转换器

    公开(公告)号：US5621620A

    公开(公告)日：1997-04-15

    申请号：US526963

    申请日：1995-09-12

    申请人： Haruhiko Machida ,  Shinichi Tasaki

    发明人： Haruhiko Machida ,  Shinichi Tasaki

    IPC分类号： H02M3/155 ,  H03K3/354 ,  H03K4/54 ,  H02M3/337

    CPC分类号： H02M3/155

    摘要： A converter for raising a weak input DC voltage of 0.3 volts or less to an output voltage has a blocking oscillator and a field-effect transistor included in the oscillator. The transistor having a base earthed is of the enhancement type activated by a gate-source voltage equal to or lower than the input, and the oscillator is activated responding to the gate-source voltage, so that pulses are generated as the output. Typically, the oscillator is composed of a resistor and a condenser connected in series through a lead and between an earth and an input line, a transformer whose secondary winding is connected to transistor's gate and the lead, with a primary winding being connected to the input line and the transistor's drain, and a diode earthed and having a cathode connected to the gate. An electromotive force induced through the secondary winding when the transistor is inactivated has positive and negative poles directed to the condenser and the gate, respectively.

    摘要翻译： 用于将输入电压为0.3V以下的弱输入直流电压升压的转换器具有包含在振荡器中的阻塞振荡器和场效应晶体管。 具有基极接地的晶体管是由等于或低于输入的栅极 - 源极电压激活的增强型，并且振荡器响应于栅极 - 源极电压被激活，使得产生脉冲作为输出。 通常，振荡器由电阻器和电容器组成，它们通过引线串联连接在地线和输入线之间，其次级绕组连接到晶体管的栅极和引线上，其中初级绕组连接到输入端 线路和晶体管的漏极，以及二极管接地并具有连接到栅极的阴极。 当晶体管失活时，通过次级绕组感应的电动势分别具有指向冷凝器和栅极的正极和负极。