发明授权
- 专利标题: Process for producing cyclohexylbutyric acid derivative
- 专利标题(中): 环己基丁酸衍生物的制备方法
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申请号: US175505申请日: 1993-12-30
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公开(公告)号: US5442105A公开(公告)日: 1995-08-15
- 发明人: Noboru Sayo , Noboru Sano , Hidenori Kumobayashi
- 申请人: Noboru Sayo , Noboru Sano , Hidenori Kumobayashi
- 申请人地址: JPX Tokyo
- 专利权人: Takasago International Corporation
- 当前专利权人: Takasago International Corporation
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX3-150224 19910621
- 主分类号: C07C69/675
- IPC分类号: C07C69/675 ; C07C227/32 ; C07C229/28 ; C07C247/12 ; C07D303/48 ; C07C61/08
摘要:
A process for for producing a (2R,3S)-cyclohexylnorstatine or a salt thereof is disclosed, which comprises the steps of: enantioselectively hydrogenating a 4-cyclohexyl-2-halogeno-3-oxobutyric acid ester in the presence of a ruthenium-phosphine complex to produce a 4-cyclohexyl-2-halogeno-(3R)-hydroxybutyric acid ester (2); epoxidizing the compound (2) in the presence of a base to produce a 4-cyclohexyl-(2S,3R)-epoxybutyric acid ester (3); reacting the compound (3) with a lower trialkylsilyl azide in the presence of a Lewis acid to produce a (3S)-azide-4-cyclohexyl-(2S)-substituted butyric acid ester (4); subjecting the compound (4) to hydrogenolysis to produce a (2S,3S)-cyclohexylnorstatine derivative (5); and inverting the configuration at the 2-position of the compound (5).
公开/授权文献
- US6015978A Resonance tunnel device 公开/授权日:2000-01-18