发明授权
- 专利标题： Benzene derivatives and method of treating arteriosclerosis with benzene derivatives
- 专利标题（中）： 苯衍生物和苯衍生物治疗动脉硬化的方法
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申请号： US182061申请日： 1994-05-19
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公开(公告)号： US5462958A公开(公告)日： 1995-10-31
- 发明人: Kenji Hayashi , Nobuhisa Watanabe , Koichi Nose , Hiroshi Tanaka , Issei Ohtsuka , Motoji Kokushi , Hironobu Hiyoshi , Hiroko Kobayashi , Toshie Yamada , Toru Horie
- 申请人： Kenji Hayashi , Nobuhisa Watanabe , Koichi Nose , Hiroshi Tanaka , Issei Ohtsuka , Motoji Kokushi , Hironobu Hiyoshi , Hiroko Kobayashi , Toshie Yamada , Toru Horie
- 申请人地址： JPX Tokyo
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX4-213242 19920720; JPX4-283432 19920930
- 主分类号： C07C275/34
- IPC分类号： C07C275/34 ; C07D233/54 ; C07D233/60 ; C07D233/64 ; A61K31/415 ; A61K31/195
摘要：
The present invention provides a novel benzene derivative useful as a preventive and medically treating medicine for arteriosclerosis, and a cholesterol O-acyl transferase inhibitor comprising the benzene derivative as an active ingredient.The benzene derivative according to the present invention is represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a carboxyl group which may be protected or a group represented by the formula: ##STR2## wherein R.sup.5 represents a lower alkyl group or a hydroxyalkyl group and R.sup.6 represents a hydrogen atom or a hydroxyl group; R.sup.2 represents a hydrogen atom, a lower alkyl group or the like; R.sup.3 and R.sup.4 each represent a hydrogen atom or a hydroxyl group; and p is an integer of 1 to 6.
公开/授权文献
- USD314299S Table leg 公开/授权日：1991-02-05