摘要:
The present invention provides a novel benzene derivative useful as a preventive and medically treating medicine for arteriosclerosis, and a cholesterol O-acyl transferase inhibitor comprising the benzene derivative as an active ingredient.The benzene derivative according to the present invention is represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a carboxyl group which may be protected or a group represented by the formula: ##STR2## wherein R.sup.5 represents a lower alkyl group or a hydroxyalkyl group and R.sup.6 represents a hydrogen atom or a hydroxyl group; R.sup.2 represents a hydrogen atom, a lower alkyl group or the like; R.sup.3 and R.sup.4 each represent a hydrogen atom or a hydroxyl group; and p is an integer of 1 to 6.
摘要:
A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101-R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10-R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.
摘要翻译:由下式表示的2-亚氨基吡咯烷衍生物:其中环B表示苯环,吡啶环等; R 101为-O-,卤素,C 1-6烷基等; R 5表示氢,C 1-6烷基,C 1-6烷氧基-C 1-6烷基 等等 R 6表示氢,C 1-6烷基,C 1-6烷氧基羰基等; Y 1表示单键,-CH 2 - 等; Y 2表示单键,-CO-等; 和Ar表示氢,由下式表示的基团:其中R 10 -R 14表示氢,C 1-6烷基,羟基 C 1-6烷氧基等; 并且R 11和R 12或R 12和R 13可以键合在一起形成5-8个 - 杂环]等,或其盐。
摘要:
A 2-iminoimidazole derivative represented by the formula: {wherein R1, R2 and R3 represent hydrogen, optionally substituted C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10-R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc., and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocycle], etc.}or salt thereof.
摘要翻译:由下式表示的2-亚氨基咪唑衍生物:其中R 1,R 2和R 3表示氢,任选取代的C 1-6烷基等; R 6表示氢,C 1-6烷基,C 1-6烷氧羰基等; Y 1表示单键,-CH 2 - 等; Y 2表示单键,-CO-等; 并且Ar表示氢,由下式表示的基团:其中R 10 -R 14表示氢,C 1-6烷基,羟基,C 1-6烷氧基等,R 11和R 12 >或R 12和R 13可以键合在一起形成5-至8-元杂环等}或其盐。
摘要:
A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101–R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10—R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.
摘要翻译:由下式表示的2-亚氨基吡咯烷衍生物:其中环B表示苯环,吡啶环等; R 101为-O-,卤素,C 1-6烷基等; R 5表示氢,C 1-6烷基,C 1-6烷氧基-C 1-6烷基 等等 R 6表示氢,C 1-6烷基,C 1-6烷氧基羰基等; Y 1表示单键,-CH 2 - 等; Y 2表示单键,-CO-等; 和Ar表示氢,由下式表示的基团:其中R 10 -R 14表示氢,C 1-6烷基,羟基 C 1-6烷氧基等; 并且R 11和R 12或R 12和R 13可以键合在一起形成5-8个 - 杂环]等,或其盐。
摘要:
A cyclic amidine derivative represented by the formula: [wherein R1, R2 and R3 represent hydrogen, C1-6 alkyl, aryl-C1-6 alkyl, etc.; R4, R5 and R7 represent hydrogen, C1-6 alkyl, etc.; Z represents 0 or 1; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; n represents 1 or 2; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; Ar represents hydrogen, a group represented by the formula: [wherein R10-R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc., and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocycle], etc.] or a salt thereof.
摘要:
A 2-iminoimidazole derivative represented by the formula: {wherein R1, R2 and R3 represent hydrogen, optionally substituted C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10–R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc., and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocycle], etc.}or salt thereof.
摘要:
A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101-R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10—R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.
摘要翻译:由下式表示的2-亚氨基吡咯烷衍生物:其中环B表示苯环,吡啶环等; R 101 -R 103代表氢,卤素,C 1-6烷基等; R 5表示氢,C 1-6烷基,C 1-6烷氧基-C 1-6烷基等; R 6表示氢,C 1-6烷基,C 1-6烷氧羰基等; Y 1表示单键,-CH 2 - 等; Y 2表示单键,-CO-等; 并且Ar表示氢,由下式表示的基团:其中R 10 -R 14表示氢,C 1-6烷基,羟基,C 1-6烷氧基等; 和R 11和R 12或R 12和R 13可以键合在一起形成5-至8-元杂环]等,或其盐。
摘要:
It is an object of the present invention to provide a polynucleotide, which can effectively suppress the immunoreactivity caused by DNA having a CpG motif and which can be used for preventing and/or treating immune-mediated diseases such as arthritis. The present invention provides a polynucleotide comprising a CpG motif wherein guanine is methylated, and a pharmaceutical composition comprising the above-mentioned polynucleotide.
摘要:
An apparatus for controlling dissolved oxygen concentration in primary and secondary cooling water in boiling water and pressurized water atomic reactors is disclosed. The apparatus contains an electrolytic cell having an anode chamber and a cathode chamber separated from one another by a diaphragm of a solid polymer electrolyte membrane. The diaphragm contains: (a) an ion exchange membrane and (b) a pair of multilayered electrodes chemically plated to both surfaces of the ion exchange membrane. The electrolytic cell is operatively connected to a circular route for cooling water in the reactor, and hydrogen gas generated through electrolysis of deionized water in the cathode side of the cell is introduced into the circular route for the cooling water to control the dissolved oxygen concentration of the cooling water.
摘要:
The purpose of the invention is to provide an antibody which recognizes OPN N-half but does not recognize the full-length OPN, and its use. A monoclonal antibody which is characterized in that it recognizes a protein or polypeptide in which the C-terminal amino acid sequence is YGLR (SEQ ID NO: 1) and it substantially does not recognize a protein or polypeptide which has an amino acid sequence of YGLR outside of the C-terminal, as well as a method for measuring OPN N-half utilizing the said antibody, a method for diagnosing diseases relating to OPN N-half, a method for judging the severity of said disease, and a method for treating said diseases, are provided.
摘要翻译:本发明的目的是提供一种识别OPN N半但不识别全长OPN的抗体及其用途。 一种单克隆抗体,其特征在于其识别C末端氨基酸序列是YGLR(SEQ ID NO:1)的蛋白质或多肽,并且其基本上不识别具有YGLR的氨基酸序列的蛋白质或多肽 C端以外的方法,以及利用所述抗体测定OPN N-half的方法,用于诊断与OPN N一半有关的疾病的方法,所述疾病的严重程度的判定方法及治疗方法 说疾病是提供的。