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US5473049A Process for obtaining proinsulin possessing correctly linked cystine bridges 失效
获得具有正确连接的胱氨酸桥的胰岛素原的方法

Process for obtaining proinsulin possessing correctly linked cystine
bridges
摘要:
A process is described for obtaining proinsulin possessing correctly linked cystine bridges from a corresponding proinsulin amino acid chain in the presence of mercaptan and chaotropic auxiliary agents and at a pH of 10 to 11, as well as its direct isolation from the reaction mixture using hydrophobic adsorber resins.
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