发明授权
US5473049A Process for obtaining proinsulin possessing correctly linked cystine
bridges
失效
获得具有正确连接的胱氨酸桥的胰岛素原的方法
- 专利标题: Process for obtaining proinsulin possessing correctly linked cystine bridges
- 专利标题(中): 获得具有正确连接的胱氨酸桥的胰岛素原的方法
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申请号: US160376申请日: 1993-12-01
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公开(公告)号: US5473049A公开(公告)日: 1995-12-05
- 发明人: Rainer Obermeier , Martin Gerl , Jurgen Ludwig , Walter Sabel
- 申请人: Rainer Obermeier , Martin Gerl , Jurgen Ludwig , Walter Sabel
- 申请人地址: DEX Frankfurt
- 专利权人: Hoechst Aktiengesellschaft
- 当前专利权人: Hoechst Aktiengesellschaft
- 当前专利权人地址: DEX Frankfurt
- 优先权: DEX4240420.7 19921202
- 主分类号: C07K14/575
- IPC分类号: C07K14/575 ; A61K38/28 ; A61P3/08 ; C07K1/113 ; C07K1/20 ; C07K14/62 ; C07K19/00 ; C12N15/00 ; C12P21/02
摘要:
A process is described for obtaining proinsulin possessing correctly linked cystine bridges from a corresponding proinsulin amino acid chain in the presence of mercaptan and chaotropic auxiliary agents and at a pH of 10 to 11, as well as its direct isolation from the reaction mixture using hydrophobic adsorber resins.
公开/授权文献
- US4892501A Doll's head and method of fabrication 公开/授权日:1990-01-09
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