发明授权
US5473076A Enantiomerically pure intermediates for (quinolin-2-yl-methoxy)
phenylacetic acids
失效
(喹啉-2-基 - 甲氧基)苯乙酸的对映异构纯中间体
- 专利标题: Enantiomerically pure intermediates for (quinolin-2-yl-methoxy) phenylacetic acids
- 专利标题(中): (喹啉-2-基 - 甲氧基)苯乙酸的对映异构纯中间体
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申请号: US164674申请日: 1993-12-08
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公开(公告)号: US5473076A公开(公告)日: 1995-12-05
- 发明人: Matthias Decker , Klaus-Helmut Mohrs , Siegfried Raddatz
- 申请人: Matthias Decker , Klaus-Helmut Mohrs , Siegfried Raddatz
- 申请人地址: DEX Leverkussen
- 专利权人: Bayer Aktiengesellschaft
- 当前专利权人: Bayer Aktiengesellschaft
- 当前专利权人地址: DEX Leverkussen
- 优先权: DEX4112533.9 19910417
- 主分类号: A61K31/47
- IPC分类号: A61K31/47 ; C07B53/00 ; C07D215/14 ; C07D215/18 ; C07D215/20 ; C07D215/38
摘要:
(Quinolin-2-yl-methoxy)phenylacetic acids are known as inhibitors of enzymatic reactions in the context of arachidonic acid metabolism. Enantiomerically pure (quinolin-2-yl-methoxy)phenylacetic acids can be prepared in a simple manner and in high purity and yield by diastereoselective alkylation of corresponding (quinolin-2-yl-methoxy)phenylacetic acid menthyl esters and subsequent specific removal of the ester radical with acids.
公开/授权文献
- US5001753A Crytographic system and process and its application 公开/授权日:1991-03-19