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    Substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphon-amides and -cyanamides, processes for their preparation and their use in medicaments
    4.
    发明授权
    Substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphon-amides and -cyanamides, processes for their preparation and their use in medicaments 失效
    取代的（喹啉-2-基 - 甲氧基）苯基 - 亚氨基 - 磺酰胺和 - 亚胺，其制备方法及其在药物中的用途

    公开(公告)号：US5091392A

    公开(公告)日：1992-02-25

    申请号：US517108

    申请日：1990-05-01

    申请人： Siegfried Raddatz ,  Klaus-Helmut Mohrs ,  Romanis Fruchtmann ,  Christian Kohlsdorfer ,  Pia Theisen-Popp ,  Reiner Muller-Peddinghaus

    发明人： Siegfried Raddatz ,  Klaus-Helmut Mohrs ,  Romanis Fruchtmann ,  Christian Kohlsdorfer ,  Pia Theisen-Popp ,  Reiner Muller-Peddinghaus

    IPC分类号： A61K31/47 ,  A61P1/00 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/08 ,  A61P43/00 ,  C07D215/14 ,  C07D215/18 ,  C07D215/20 ,  C07D215/38

    CPC分类号： C07D215/14

    摘要： A quinolin-2-yl-methoxy)phenylacyl-sulphonamide or -cyanamide of the formula ##STR1## in which A, B, D, E, F and G are identical or different andrepresent hydrogen, hydroxyl, halogen, carboxyl, nitro, trifluoromethyl, trifluoromethoxy or a group of the formula --NH.sup.3 R.sup.4, in whichR.sup.3 and R.sup.4 are identical or different and denote hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or aryl having 6 to 10 carbon atoms,represent straight-chain or branched alkyl, alkoxy or alkoxycarbonyl in each case having up to 12 carbon atoms,represent aryl having 6 to 10 carbon atoms,R.sup.1 represents cycloalkyl having 3 to 8 carbon atoms,R.sup.2 represents hydrogen orstraight-chain or branched alkyl having up to 10 carbon atoms,represents an alkali metal,represents cycloalkyl having 3 to 8 carbon atoms,X represents a group of the formula --SO.sub.2 --R.sup.5, in whichR.sup.5 denotes trifluoromethyl or straight-chain or branches alkyl having up to 10 carbon atoms, ordenotes aryl having 6 to 10 carbon atoms, orX represents cyanoand physiologically acceptable salts thereof.The (quinolin-2-yl-methoxy)phenylacylsulphonamide or -cyanamide is useful as an active compound in medicaments, particularly as a lipoxygenase inhibitor.

    摘要翻译： 其中A，B，D，E，F和G相同或不同并且表示氢，羟基，卤素，羧基的式（I）的喹啉-2-基 - 甲氧基）苯甲酰基 - 磺酰胺或氰基酰胺 硝基，三氟甲基，三氟甲氧基或式-NH 3 R 4基团，其中R 3和R 4相同或不同并且表示氢，具有至多8个碳原子的直链或支链烷基或具有6至10个碳原子的芳基表示 在每种情况下具有至多12个碳原子的直链或支链烷基，烷氧基或烷氧基羰基表示具有6至10个碳原子的芳基，R 1表示具有3至8个碳原子的环烷基，R 2表示氢或具有直链或支链烷基的直链或支链烷基， 至多10个碳原子，代表碱金属，代表具有3-8个碳原子的环烷基，X代表式-SO2-R5的基团，其中R5代表三氟甲基或直链或支链烷基，最多具有10个碳原子 ，或表示具有6〜10个碳的芳基 或X表示氰基及其生理上可接受的盐。 （喹啉-2-基 - 甲氧基）苯基酰基磺酰胺或氰基酰胺可用作药物中的活性化合物，特别是脂氧合酶抑制剂。