发明授权
US5480793A Nucleic acid coding for the human angiotensin converting enzyme (ACE),
and its uses, especially for the in vitro diagnosis of arterial
hypertension
失效
编码人血管紧张素转换酶（ACE）的核酸及其用途，特别是动脉高压的体外诊断
- 专利标题： Nucleic acid coding for the human angiotensin converting enzyme (ACE), and its uses, especially for the in vitro diagnosis of arterial hypertension
- 专利标题（中）： 编码人血管紧张素转换酶（ACE）的核酸及其用途，特别是动脉高压的体外诊断
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申请号： US288709申请日： 1994-08-12
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公开(公告)号： US5480793A公开(公告)日： 1996-01-02
- 发明人: Florent Soubrier , Francois Alhenc-Gelas , Christine Hubert , Pierre Corvol
- 申请人： Florent Soubrier , Francois Alhenc-Gelas , Christine Hubert , Pierre Corvol
- 申请人地址： FRX Paris
- 专利权人： Institut National De La Sante Et De La Recherche Medicale
- 当前专利权人： Institut National De La Sante Et De La Recherche Medicale
- 当前专利权人地址： FRX Paris
- 优先权： FRX8812620 19880927
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; C07K16/40 ; C12N7/00 ; C12N9/48 ; C12N9/64 ; C12N15/16 ; C12N15/57 ; C12P21/08 ; C12Q1/68 ; C12N1/21 ; C12N15/63 ; C12P21/02
摘要：
The invention relates to the cloning and sequencing of the nucleic acid coding for the human ACE as well as the determination of the peptide chain corresponding to the ACE and of active peptide fragments which derive from it.Another subject of the invention is the utilization of the above-mentioned polypeptides for the implementation of in vitro diagnostic methods for hypertension and for the design of new inhibitors of the ACE.The invention also relates to the utilization of the nucleotide probes of the invention for the in vitro screening of the polymorphisms of the gene coding for the ACE.
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