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1.发明授权Nucleic acid coding for the human angiotensin converting enzyme (ACE), and its uses, especially for the in vitro diagnosis of arterial hypertension 失效编码人血管紧张素转换酶（ACE）的核酸及其用途，特别是动脉高压的体外诊断
公开(公告)号：US5480793A
公开(公告)日：1996-01-02
申请号：US288709
申请日：1994-08-12
IPC分类号： C12N15/09 , A61K38/00 , C07K16/40 , C12N7/00 , C12N9/48 , C12N9/64 , C12N15/16 , C12N15/57 , C12P21/08 , C12Q1/68 , C12N1/21 , C12N15/63 , C12P21/02
CPC分类号： C12Q1/6827 , C07K16/40 , C12N9/48 , C12Q1/683 , C12Q1/6883 , A61K38/00 , C12Q2600/156
摘要： The invention relates to the cloning and sequencing of the nucleic acid coding for the human ACE as well as the determination of the peptide chain corresponding to the ACE and of active peptide fragments which derive from it.Another subject of the invention is the utilization of the above-mentioned polypeptides for the implementation of in vitro diagnostic methods for hypertension and for the design of new inhibitors of the ACE.The invention also relates to the utilization of the nucleotide probes of the invention for the in vitro screening of the polymorphisms of the gene coding for the ACE.
摘要翻译： 本发明涉及编码人ACE的核酸的克隆和测序，以及对应于ACE的肽链和从其衍生的活性肽片段的测定。 本发明的另一主题是利用上述多肽来实施高血压的体外诊断方法和设计ACE的新抑制剂。 本发明还涉及本发明的核苷酸探针用于体外筛选编码ACE的基因的多态性的用途。
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2.发明授权Nucleic acid coding for the human angiotensin converting enzyme (ACE), and its uses, especially for the in vitro diagnosis of arterial hypertension 失效编码人血管紧张素转换酶（ACE）的核酸及其用途，特别是动脉高压的体外诊断
公开(公告)号：US5359045A
公开(公告)日：1994-10-25
申请号：US460126
申请日：1990-05-23
IPC分类号： C12N15/09 , A61K38/00 , C07K16/40 , C12N7/00 , C12N9/48 , C12N9/64 , C12N15/16 , C12N15/57 , C12P21/08 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6827 , C07K16/40 , C12N9/48 , C12Q1/683 , C12Q1/6883 , A61K38/00 , C12Q2600/156
摘要： The invention relates to the cloning and sequencing of the nucleic acid coding for the human ACE as well as the determination of the peptide chain corresponding to the ACE and of active peptide fragments which derive from it.Another subject of the invention is the utilization of the above-mentioned polypeptides for the implementation of in vitro diagnostic methods for hypertension and for the design of new inhibitors of the ACE.The invention also relates to the utilization of the nucleotide probes of the invention for the in vitro screening of the polymorphisms of the gene coding for the ACE.
摘要翻译： PCT No.PCT / FR89 / 00496 Sec。 371日期1990年5月23日 102（e）日1990年5月23日PCT 1989年9月27日PCT PCT。 出版物WO90 / 03435 日本1990年04月5日。本发明涉及编码人ACE的核酸的克隆和测序，以及对应于ACE的肽链和从其衍生的活性肽片段的测定。 本发明的另一主题是利用上述多肽来实施高血压的体外诊断方法和设计ACE的新抑制剂。 本发明还涉及本发明的核苷酸探针用于体外筛选编码ACE的基因的多态性的用途。
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