发明授权
- 专利标题: Benzanilide derivatives
- 专利标题(中): 苯甲酰苯胺衍生物
-
申请号: US237297申请日: 1994-05-03
-
公开(公告)号: US5510350A公开(公告)日: 1996-04-23
- 发明人: Alexander W. Oxford , William L. Mitchell , John Bradshaw , John W. Clitherow , Malcolm Carter
- 申请人: Alexander W. Oxford , William L. Mitchell , John Bradshaw , John W. Clitherow , Malcolm Carter
- 申请人地址: GB2
- 专利权人: Glaxo Group Limited
- 当前专利权人: Glaxo Group Limited
- 当前专利权人地址: GB2
- 优先权: GBX9119931 19910918; GBX9205338 19920312
- 主分类号: A61K31/495
- IPC分类号: A61K31/495 ; A61K20060101 ; A61K31/165 ; A61K31/41 ; A61K31/496 ; A61K31/53 ; A61P5/00 ; A61P9/12 ; A61P15/10 ; A61P25/00 ; A61P25/16 ; A61P25/22 ; A61P25/24 ; A61P25/26 ; A61P25/28 ; C07D20060101 ; C07D249/04 ; C07D249/06 ; C07D249/08 ; C07D249/14 ; C07D271/06 ; C07D271/07 ; C07D271/08 ; C07D271/10 ; C07D271/107 ; C07D285/06 ; C07D285/08 ; C07D285/10 ; C07D285/12 ; C07D285/125 ; C07D403/12 ; C07D413/12 ; C07D417/12
摘要:
The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt or solvate thereof wherein R.sup.1 represents a hydrogen atom or a halogen atom or a group selected from C.sub.1-6 alkyl and C.sub.1-6 alkoxy;R.sup.2 represents a phenyl group substituted by a group selected from ##STR2## and optionally further substituted by one or two substituents selected from halogen atoms, C.sub.1-6 alkoxy, hydroxy, and C.sub.1-6 alkyl;R.sup.3 represents the group ##STR3## R.sup.4 and R.sup.5, which may be the same or different, each independently represent a hydrogen atom or a halogen atom or a group selected from hydroxy, C.sub.1-6 alkoxy and C.sub.1-6 alkyl;R.sup.6 represents a hydrogen atom or a group selected from --NR.sup.9 R.sup.10 and a C.sub.1-6 alkyl group optionally substituted by one or two substituents selected from C.sub.1-6 alkoxy, hydroxy, C.sub.1-6 acyloxy and --SO.sub.2 R.sup.11 ;R.sup.7, R.sup.8 and R.sup.9, which may be the same or different, each independently represent a hydrogen atom or a C.sub.1-6 alkyl group;R.sup.10 represents a hydrogen atom or a group selected from C.sub.1-6 alkyl, C.sub.1-6 acyl, benzoyl and --SO.sub.2 R.sup.11 ;R.sup.11 represents a C.sub.1-6 alkyl group or a phenyl group;Z represents an oxygen atom or a group selected from NR.sup.8 and S(O).sub.k ; andk represents zero, 1 or 2.The compounds may be used in the treatment or prophylaxis of depression and other CNS disorders.
公开/授权文献
- US06085426A Dispensing razor blade cartridges used with a handle 公开/授权日:2000-07-11