发明授权
US5510522A Synthesis of
N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine
ethyl ester and its regioselective radiofluorodestannylation to
6- .sup.18 F!fluoro-1-dopa
失效
N-甲酰基-3,4-二叔丁氧基羰基氧基-6-（三甲基甲锡烷基）-L-苯丙氨酸乙酯的合成及其对6- [18 F]氟-1-多巴的区域选择性全氟代去甲硅烷基化
- 专利标题： Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- .sup.18 F!fluoro-1-dopa
- 专利标题（中）： N-甲酰基-3,4-二叔丁氧基羰基氧基-6-（三甲基甲锡烷基）-L-苯丙氨酸乙酯的合成及其对6- [18 F]氟-1-多巴的区域选择性全氟代去甲硅烷基化
-
申请号： US393428申请日： 1995-02-22
-
公开(公告)号： US5510522A公开(公告)日： 1996-04-23
- 发明人: Nagichettiar Satyamurthy , Jorge R. Barrio , Allyson J. Bishop , Mohammad Namavari , Gerald T. Bida
- 申请人： Nagichettiar Satyamurthy , Jorge R. Barrio , Allyson J. Bishop , Mohammad Namavari , Gerald T. Bida
- 申请人地址： CA Oakland
- 专利权人： Regents of the University of California
- 当前专利权人： Regents of the University of California
- 当前专利权人地址： CA Oakland
- 主分类号： C07B59/00
- IPC分类号： C07B59/00 ; C07C215/52 ; C07C229/36 ; C07C229/00
摘要：
A process for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver trifluoroacetic acid; (b) Bb.sub.3 ; (c) dit-butyldicarbonate; (d) hexamethyltin; (e) a fluoro compound; (f) hydrobromic acid; and (g) raising the pH to .ltoreq.7.
公开/授权文献
- US4615274A Indexing conveyor for robotic production operations 公开/授权日：1986-10-07
信息查询
