发明授权
US5521212A Cyclopropyl N-hydroxyurea and N-hydroxyacetamides which inhibit
lipoxygenase
失效
抑制脂氧合酶的环丙基N-羟基脲和N-羟基乙酰胺
- 专利标题: Cyclopropyl N-hydroxyurea and N-hydroxyacetamides which inhibit lipoxygenase
- 专利标题(中): 抑制脂氧合酶的环丙基N-羟基脲和N-羟基乙酰胺
-
申请号: US244739申请日: 1994-08-26
-
公开(公告)号: US5521212A公开(公告)日: 1996-05-28
- 发明人: Takafumi Ikeda , Akiyoshi Kawai , Takashi Mano , Yoshiyuki Okumura , Rodney W. Stevens
- 申请人: Takafumi Ikeda , Akiyoshi Kawai , Takashi Mano , Yoshiyuki Okumura , Rodney W. Stevens
- 申请人地址: NY New York
- 专利权人: Pfizer Inc.
- 当前专利权人: Pfizer Inc.
- 当前专利权人地址: NY New York
- 优先权: JPX3-330485 19911213
- 主分类号: C07C259/06
- IPC分类号: C07C259/06 ; C07C275/64 ; C07C323/44 ; C07D295/15 ; A61K31/40 ; A61K31/33 ; A61K31/445 ; C07D295/195
摘要:
Compounds of the formula ##STR1## wherein A is C1 to C3 alkylene, Ar is phenyl or styryl, R is halosubstituted C1 to C3 alkyl, NHR' or ##STR2## R' is hydrogen or C2 to C8 alkytthioalkyl, n is an integer of from 1 to 4 and p is an integer of from 2 to 5, with the proviso that when R' is hydrogen then Ar is styryl, and the pharmaceutically acceptable salts thereof, inhibit the enzyme lipoxygenase and are useful in treating allergy and inflammatory and cardiovascular conditions for which the action of lipoxygenase has been implicated. These compounds form the active ingredient in pharmaceutical compositions for treating such conditions.
公开/授权文献
- US4409585A System governing the position of a sensor 公开/授权日:1983-10-11