发明授权
US5521212A Cyclopropyl N-hydroxyurea and N-hydroxyacetamides which inhibit lipoxygenase 失效
抑制脂氧合酶的环丙基N-羟基脲和N-羟基乙酰胺

Cyclopropyl N-hydroxyurea and N-hydroxyacetamides which inhibit
lipoxygenase
摘要:
Compounds of the formula ##STR1## wherein A is C1 to C3 alkylene, Ar is phenyl or styryl, R is halosubstituted C1 to C3 alkyl, NHR' or ##STR2## R' is hydrogen or C2 to C8 alkytthioalkyl, n is an integer of from 1 to 4 and p is an integer of from 2 to 5, with the proviso that when R' is hydrogen then Ar is styryl, and the pharmaceutically acceptable salts thereof, inhibit the enzyme lipoxygenase and are useful in treating allergy and inflammatory and cardiovascular conditions for which the action of lipoxygenase has been implicated. These compounds form the active ingredient in pharmaceutical compositions for treating such conditions.
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