发明授权
- 专利标题: Aminoalkylpyrrolidinylthiocarbapenem derivatives
- 专利标题(中): 氨基烷基吡咯烷基硫代碳青霉烯衍生物
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申请号: US312619申请日: 1994-09-27
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公开(公告)号: US5550121A公开(公告)日: 1996-08-27
- 发明人: Susumu Nakagawa , Shinji Kato , Satoshi Murase , Osamu Okamoto , Ryuji Mitomo , Katsumi Yamamoto , Koji Yamada , Hiroshi Fukatsu
- 申请人: Susumu Nakagawa , Shinji Kato , Satoshi Murase , Osamu Okamoto , Ryuji Mitomo , Katsumi Yamamoto , Koji Yamada , Hiroshi Fukatsu
- 申请人地址: JPX Tokyo
- 专利权人: Banyu Pharmaceutical Co., Ltd.
- 当前专利权人: Banyu Pharmaceutical Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX3-335888 19911127; JPX4-215613 19920721
- 主分类号: C07D207/12
- IPC分类号: C07D207/12 ; C07D477/20 ; C07D487/04 ; A61K31/40
摘要:
A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is a hydrogen atom or a negative charge, R.sup.3 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group, a lower alkanoyloxy group, an amino group, an N-lower alkylamino group, an N,N-di-lower alkylamino group, a lower alkanoylamino group, an aroylamino group, a (lower alkylsulfonyl)amino group, a sulfamoylamino group, a cyano group, a nitro group, a group of --COOR.sup.4 (wherein R.sup.4 is a hydrogen atom or a lower alkyl group) or a group of --CON(R.sup.5)R.sup.6 (wherein each of R.sup.5 and R.sup.6 which may be the same or different, is a hydrogen atom or a lower alkyl group, or R.sup.5 and R.sup.6 form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidyl group, a piperazinyl group, a 4-lower alkyl piperazinyl group and a morpholino group), A is a linear or branched lower alkylene group, X is a group of --N(R.sup.7)R.sup.8 (wherein each of R.sup.7 and R.sup.8 which may be the same or different, is a hydrogen atom or a lower alkyl group) or a group of --N.sup.+ (R.sup.9)(R.sup.10)R.sup.11 (wherein each of R.sup.9, R.sup.10 and R.sup.11 which may be the same or different, is a lower alkyl group), provided that when A is a linear lower alkylene group, R.sup.3 is other than a hydrogen atom; or a pharmaceutically acceptable salt or ester thereof.
公开/授权文献
- US4941980A System for measuring a topographical feature on a specimen 公开/授权日:1990-07-17
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