发明授权
US5561135A N,N,N',N'-tetrasubstituted-1,2-ethanediamine derivative compounds
失效
N，N，N'，N'-四取代-1,2-乙二胺衍生物化合物
- 专利标题： N,N,N',N'-tetrasubstituted-1,2-ethanediamine derivative compounds
- 专利标题（中）： N，N，N'，N'-四取代-1,2-乙二胺衍生物化合物
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申请号： US392987申请日： 1995-04-21
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公开(公告)号： US5561135A公开(公告)日： 1996-10-01
- 发明人: Rafael Foguet , Santiago Gubert , Jos e Ortiz , Aurelio Sacrist an , Josep M. Castell o
- 申请人： Rafael Foguet , Santiago Gubert , Jos e Ortiz , Aurelio Sacrist an , Josep M. Castell o
- 申请人地址： ESX Barcelona
- 专利权人： Ferrer Internacional, S.A.
- 当前专利权人： Ferrer Internacional, S.A.
- 当前专利权人地址： ESX Barcelona
- 优先权： ESX9301616 19930719
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; A61P25/18 ; C07C209/04 ; C07C211/29 ; C07C215/30 ; C07C225/06 ; C07C225/16 ; C07D239/42 ; C07D319/08 ; A61K31/135
摘要：
The invention relates to new N,N,N'N'-tetra-substituted-1,2-ethanediamine compounds of the general formula (I): ##STR1## wherein X is a carbonyl (CO), hydroxymethylen (CHOH) or p-fluorophenyl-methylen (p--F--C.sub.6 H.sub.4 --CH) group and R is a benzyl group optionally substituted in p-- with an halogen, or R is a 2-pyrimidinyl group with the proviso that simultaneously X may not be p-fluorophenyl-methylen (p--F--C.sub.6 H.sub.4 --CH) and R may not be an unsubstituted benzyl group, as well as their pharmaceutically acceptable additions salts.The compounds are potentially useful in the treatment of sigma receptor-related nervous system diseases.
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