发明授权
US5565322A Hybridization of polynucleotides conjugated with chromophores and
fluorophores to generate donor-to donor energy transfer system
失效
与发色团和荧光团缀合的多核苷酸的杂交以产生供体 - 给体能量转移系统
- 专利标题： Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfer system
- 专利标题（中）： 与发色团和荧光团缀合的多核苷酸的杂交以产生供体 - 给体能量转移系统
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申请号： US232233申请日： 1994-05-05
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公开(公告)号： US5565322A公开(公告)日： 1996-10-15
- 发明人: Michael J. Heller
- 申请人： Michael J. Heller
- 申请人地址： CA San Diego
- 专利权人： Nanogen, Inc.
- 当前专利权人： Nanogen, Inc.
- 当前专利权人地址： CA San Diego
- 主分类号： G01N33/533
- IPC分类号： G01N33/533 ; C07H21/00 ; C09B69/10 ; C09K11/06 ; C12N15/09 ; C12Q1/68 ; G01N33/566 ; G06N3/12 ; G11B7/0037 ; G11B7/0045 ; G11B7/005 ; G11B7/244 ; G11B7/246 ; G11C13/02 ; G11C13/04 ; H01L21/98 ; C07H21/02 ; C07H21/04
摘要：
The presence invention contemplates chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor-donor transfer distance, and at least one fluorescing acceptor chromophore operatively linked to the polynucleotide by a linker arm, such that the fluorescing acceptor chromophore is positioned by linkage at a donor-acceptor transfer distance from at least one of the donor chromophores, to form a photonic structure for collecting photonic energy and transferring the energy to an acceptor chromophore.
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