发明授权
- 专利标题: Indole derivatives
- 专利标题(中): 吲哚衍生物
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申请号: US469258申请日: 1995-06-06
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公开(公告)号: US5578612A公开(公告)日: 1996-11-26
- 发明人: John E. Macor , Martin J. Wythes
- 申请人: John E. Macor , Martin J. Wythes
- 申请人地址: NY New York
- 专利权人: Pfizer Inc.
- 当前专利权人: Pfizer Inc.
- 当前专利权人地址: NY New York
- 主分类号: A61K31/00
- IPC分类号: A61K31/00 ; A61K31/40 ; A61K31/403 ; A61K31/404 ; A61K31/4045 ; A61K31/4427 ; A61K31/445 ; A61K31/4465 ; A61K31/4523 ; A61K31/454 ; A61P1/00 ; A61P1/08 ; A61P3/00 ; A61P3/04 ; A61P9/00 ; A61P9/08 ; A61P9/12 ; A61P11/00 ; A61P17/00 ; A61P19/00 ; A61P25/04 ; A61P25/06 ; A61P25/18 ; A61P25/20 ; A61P25/24 ; A61P25/26 ; A61P25/30 ; A61P27/00 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07D401/06 ; C07D403/06
摘要:
Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, X and n are as defined in the claims and the pharmaceutically acceptable salts thereof are new. These compounds are useful psychotherapeutics and are potent serotonin (5-HT.sub.1) agonists and may be used in the treatment of depression, anxiety, eating disorders, obesity, drug abuse, cluster headache, migraine, pain, chronic paroxysmal hemicrania and headache associated with vascular disorders, and other disorders arising from deficient serotonergic neurotransmission. The compounds can also be used as centrally acting hypertensives and vasodilators. A process for forming indoles by transition metal catalyzed cyclization of dihalogenated intermediate is also disclosed.
公开/授权文献
- USD334808S Log home 公开/授权日:1993-04-13
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