发明授权
- 专利标题: Suppression of proliferative response and induction of tolerance with polymorphic class II MHC allopeptides
- 专利标题(中): 抑制增殖反应和诱导与多态II类MHC异基因的耐受性
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申请号: US27127申请日: 1993-03-05
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公开(公告)号: US5593698A公开(公告)日: 1997-01-14
- 发明人: Howard L. Weiner , David A. Hafler , Charles B. Carpenter , Mohamed Sayegh , Zhengyi Zhang
- 申请人: Howard L. Weiner , David A. Hafler , Charles B. Carpenter , Mohamed Sayegh , Zhengyi Zhang
- 申请人地址: MA Lexington
- 专利权人: Autoimmune, Inc.
- 当前专利权人: Autoimmune, Inc.
- 当前专利权人地址: MA Lexington
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; A61K35/26 ; A61K35/28 ; A61K38/00 ; A61K39/395 ; A61P37/06 ; C07K14/74 ; A61K35/14 ; A01N63/00 ; C07K1/00 ; C07K14/00
摘要:
Described are methods for: (a) suppressing the ability of T-cells from a mammal to proliferate in response to stimulation by nonself mammalian tissue; and (b) suppressing immune response which leads to allograft rejection in a mammal receiving an allograft from a donor mammal. The methods involve orally administering to the mammal to be thus treated a composition comprising at least one of: (i) a major histocompatibility complex Class II antigen from a second nonself mammal or from tissue of a mammal syngeneic to said nonself mammal; (ii) at least one synthetic peptide corresponding to a T-cell suppressive fragment of said Class II antigen, said composition being administered in an amount effective to suppress said proliferation. The foregoing compositions are also described.