发明授权
- 专利标题: Production and use of multimeric hemoglobins
- 专利标题(中): 多聚体血红蛋白的生产和使用
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申请号: US240712申请日: 1994-05-09
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公开(公告)号: US5599907A公开(公告)日: 1997-02-04
- 发明人: David C. Anderson , Antony J. Mathews , Gary L. Stetler
- 申请人: David C. Anderson , Antony J. Mathews , Gary L. Stetler
- 申请人地址: CO Boulder
- 专利权人: Somatogen, Inc.
- 当前专利权人: Somatogen, Inc.
- 当前专利权人地址: CO Boulder
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A61K47/48 ; C07K14/805 ; C12N15/12 ; C12N15/81 ; A61K35/14 ; C07H21/04 ; C12P21/00
摘要:
Multimeric hemoglobin-like proteins are obtained by crosslinking cysteines of the component tetramers, or by genetically fusing globin-like domains of one tetramer with those of another, by means of an interdomain spacer sequence. Artificial cysteines are introduced selectively in a single globin-like domain per tetramer to control polymerization.
公开/授权文献
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