发明授权
- 专利标题： Carbohydrate-directed cross-linking reagents
- 专利标题（中）： 碳水化合物导向的交联试剂
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申请号： US416402申请日： 1995-03-31
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公开(公告)号： US5605791A公开(公告)日： 1997-02-25
- 发明人: Avi J. Ashkenazi , Steven M. Chamow , Timothy P. Kogan
- 申请人： Avi J. Ashkenazi , Steven M. Chamow , Timothy P. Kogan
- 申请人地址： CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： CA South San Francisco
- 主分类号： C07D207/44
- IPC分类号： C07D207/44 ; C07D207/452 ; C07K1/107 ; C07K14/805 ; C12Q1/68 ; C12Q1/70 ; G01N33/53
摘要：
The invention provides heterobifunctional cross-linking reagents and methods of using the cross-linking reagents. The cross-linking reagents of the invention combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, allowing coupling of aldehydes to free thiols. In the methods of the invention, human immunodeficiency virus (HIV) infected cells can be detected using conjugates that include CD4 molecules conjugated to detectable markers via the disclosed cross-linking reagents.
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