A medical probe apparatus comprising a catheter having a stylet guide housing with at least one stylet port in a side thereof and a stylet guide for directing a flexible stylet outward through at least one stylet port and through intervening tissue to targeted tissues. The stylet guide has a biopsy sample device or other tissue manifesting device at the distal end thereof to gather tissue or perform other operations at the point of the desired tissue such as emitting electromagnetic energy as ablative power to target tissues.One embodiment of the biopsy sample stylet includes a hollow core sampler including a biopsy needle apparatus for gathering sample tissue. The hollow core sampler has a sharpened end for facilitating the penetration into and gathering of the sample tissue. A second embodiment of the biopsy sample stylet includes a harpoon-like sample stylet when the sharp tip thereof allows for easy entry into the target tissue. The sharpened barbed side opening allows for certain desired tissue to be sampled to be drawn into the side opening for individual cell gathering or complete sample excise or gathering of the desired tissue. The third embodiment is a clam shell or alligator type biopsy jaw device whereby the sharpened biopsy tip thereof allows a tissue sample to be clipped or cut upon activation of the stylet jaws. Still another embodiment comprises a biopsy knife device in conjunction with an electromagnetic emitter for selective tissue sampling or electromagnetic heat ablation, or both, of selected tissue.