发明授权
- 专利标题： Selection of ribozymes that efficiently cleave target RNA
- 专利标题（中）： 选择有效切割靶RNA的核酶
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申请号： US931560申请日： 1992-08-18
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公开(公告)号： US5616459A公开(公告)日： 1997-04-01
- 发明人: Fred R. Kramer , David Dubnau , Karl A. Drlica , Abraham Pinter
- 申请人： Fred R. Kramer , David Dubnau , Karl A. Drlica , Abraham Pinter
- 申请人地址： NY New York
- 专利权人： The Public Health Research Institute of the City of New York, Inc.
- 当前专利权人： The Public Health Research Institute of the City of New York, Inc.
- 当前专利权人地址： NY New York
- 主分类号： C12N9/10
- IPC分类号： C12N9/10 ; C12N15/10 ; C12N15/113 ; C12Q1/68 ; C12Q1/70 ; C07H21/02
摘要：
Mutant ribozymes are screened by culturing cells whose survival is dependant upon cleavage of RNA by a ribozyme, which cleavage causes the cells to survive in the presence of an agent which otherwise would kill the cells, and selecting cells which survive.
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