发明授权
- 专利标题： Synthetic isohirudins with improved stability
- 专利标题（中）： 具有改善稳定性的合成异染色质素
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申请号： US452829申请日： 1995-05-30
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公开(公告)号： US5616476A公开(公告)日： 1997-04-01
- 发明人: Peter Crause , Paul Habermann , Dominique Tripier , Wolfgang Ulmer , Gerhard Schmid
- 申请人： Peter Crause , Paul Habermann , Dominique Tripier , Wolfgang Ulmer , Gerhard Schmid
- 申请人地址： DEX Frankfurt am Main
- 专利权人： Hoechst Aktiengesellschaft
- 当前专利权人： Hoechst Aktiengesellschaft
- 当前专利权人地址： DEX Frankfurt am Main
- 优先权： DEX4140381.9 19911207
- 主分类号： A61K38/55
- IPC分类号： A61K38/55 ; A61K38/00 ; A61P7/02 ; C07K1/14 ; C07K14/00 ; C07K14/815 ; C12N15/09 ; C12N15/12 ; C12P21/02 ; C12R1/19 ; C12P21/06 ; C07H19/00 ; C12N5/00
摘要：
The invention relates to novel synthetic isohirudins which have improved stability owing to exchange in the region of the Asp-Gly motif. This results, on the one hand, in an increase in the yield during workup and, on the other hand, in making possible pharmaceutical formulation as directly injectable solution ready for use.
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