发明授权
US5625057A Process for preparing 2',3'-Dideoxy-2',3'-dehydronucleosides
失效
制备2'，3'-二脱氧-2'，3'-脱氢核苷的方法
- 专利标题： Process for preparing 2',3'-Dideoxy-2',3'-dehydronucleosides
- 专利标题（中）： 制备2'，3'-二脱氧-2'，3'-脱氢核苷的方法
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申请号： US295478申请日： 1994-08-25
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公开(公告)号： US5625057A公开(公告)日： 1997-04-29
- 发明人: Hiroshi Shiragami , Yumiko Uchida , Kunisuke Izawa
- 申请人： Hiroshi Shiragami , Yumiko Uchida , Kunisuke Izawa
- 申请人地址： JPX Tokyo
- 专利权人： Ajinomoto Co., Inc.
- 当前专利权人： Ajinomoto Co., Inc.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX3-245290 19910619
- 主分类号： C07D405/04
- IPC分类号： C07D405/04 ; C07D403/04 ; C07H19/06 ; C07H19/067 ; C07H1/00 ; C07H19/073
摘要：
A process for preparing a 2', 3'-dideoxy-2',3'-didehydropyrimidine nucleoside comprising reacting the pyrimidine ribofuranoside with a trialkyl orthoester to yield the 2',3'-O-alkoxyethylidene derivative; which is reacted with hydrogen bromide in acetic acid or acetyl bromide to yield the 2-deoxy-2'-bromo-3'-acetyl-pyrimidine nucleoside; which is then reduced with zinc to yield the 2',3'-olefin of the pyrimidine nucleoside.
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