发明授权
- 专利标题: Dopamine receptor subtype ligands
- 专利标题(中): 多巴胺受体亚型配体
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申请号: US424364申请日: 1995-04-20
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公开(公告)号: US5631269A公开(公告)日: 1997-05-20
- 发明人: Howard B. Broughton , Ian J. Collins , Raymond Baker , Paul D. Leeson , Michael Rowley
- 申请人: Howard B. Broughton , Ian J. Collins , Raymond Baker , Paul D. Leeson , Michael Rowley
- 申请人地址: GB2 Hoddesdon
- 专利权人: Merck Sharp & Dohme Limited
- 当前专利权人: Merck Sharp & Dohme Limited
- 当前专利权人地址: GB2 Hoddesdon
- 优先权: GBX9222263 19921023; GBX9222265 19921023
- 主分类号: A61K31/4427
- IPC分类号: A61K31/4427 ; A61K31/4433 ; A61K31/445 ; A61K31/451 ; A61P1/08 ; A61P13/02 ; A61P15/00 ; A61P25/00 ; A61P25/18 ; A61P25/24 ; A61P25/26 ; C07D211/32 ; C07D401/04 ; C07D401/06 ; C07D401/14 ; C07D403/04 ; C07D405/14 ; C07D409/04 ; C07D409/06 ; C07D409/14 ; C07D413/04 ; C07D417/04 ; C07D211/28
摘要:
Compounds of formula (I) ##STR1## wherein one of X and Y represents nitrogen, and the other of X and Y represents oxygen, sulphur or N--R.sup.2 ; Q represents a substituted five- or six- membered monocyclic heteroaliphatic ring which contains one nitrogen atom as the sole heteroatom and is linked to the five-membered heteroatomic ring containing the moieties X and Y via a carbon atom; as well as substituted 1,3-dioxopropane precursors thereto, are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment of disorders of the dopamine system, in particular schizophrenia.
公开/授权文献
- USD327718S Physical exercise stool 公开/授权日:1992-07-07
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