- 专利标题： Urethanes and ureas that induce cytokine production
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申请号： US451085申请日： 1995-05-25
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公开(公告)号： US5633280A公开(公告)日： 1997-05-27
- 发明人: Semiramis Ayral-Kaloustian , Steven R. Schow , Mila T. Du , James J. Gibbons, Jr.
- 申请人： Semiramis Ayral-Kaloustian , Steven R. Schow , Mila T. Du , James J. Gibbons, Jr.
- 申请人地址： NJ Madison
- 专利权人： American Cyanamid Company
- 当前专利权人： American Cyanamid Company
- 当前专利权人地址： NJ Madison
- 主分类号： C07D263/06
- IPC分类号： C07D263/06 ; A61K31/17 ; A61K31/27 ; A61K31/325 ; A61K38/00 ; A61K38/05 ; A61P31/12 ; A61P31/18 ; A61P35/00 ; A61P37/04 ; A61P43/00 ; C07C237/22 ; C07C269/04 ; C07C271/22 ; C07C271/24 ; C07C273/18 ; C07C275/16 ; C07C275/26 ; C07K5/02 ; C07K5/06 ; C07K5/068 ; C07K5/072
摘要：
The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.
公开/授权文献
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