发明授权
- 专利标题: Medicaments
- 专利标题(中): 药剂
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申请号: US442719申请日: 1995-05-15
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公开(公告)号: US5637611A公开(公告)日: 1997-06-10
- 发明人: Francis D. King , Laramie M. Gaster , Alberto J. Kaumann , Rodney C. Young
- 申请人: Francis D. King , Laramie M. Gaster , Alberto J. Kaumann , Rodney C. Young
- 申请人地址: GB2
- 专利权人: SmithKline Beecham p.l.c.
- 当前专利权人: SmithKline Beecham p.l.c.
- 当前专利权人地址: GB2
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; A61K31/403 ; A61K31/4427 ; A61K31/445 ; A61K31/454 ; A61P25/04 ; A61P25/06 ; A61P43/00 ; C07D20060101 ; C07D209/88 ; C07D401/04 ; C07D401/06 ; C07D401/12 ; C07D403/04 ; C07D403/06 ; C07D403/12 ; C07D209/82
摘要:
Use of a compound of general formula (I): ##STR1## wherein: R.sup.1 represents hydrogen, halogen, trifluoromethyl, nitro, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, arylC.sub.1-6 alkoxy, --CO.sub.2 R.sup.4, --(CH.sub.2).sub.n CN, --(CH.sub.2).sub.n CONR.sup.5 R.sup.6, --(CH.sub.2).sub.n SO.sub.2 NR.sup.5 R.sup.6, C.sub.1-6 alkanoylamino (CH.sub.2).sub.n, or C.sub.1-6 alkylsulphonylamino (CH.sub.2).sub.n ;R.sup.4 represents hydrogen, C.sub.1-6 alkyl or arylC.sub.1-6 alkyl;R.sup.5 and R.sup.6 each independently represent hydrogen or C.sub.1-6 alkyl, or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are attached form a ring;n represents 0, 1 or 2; andR.sup.2 and R.sup.3 each independently represent hydrogen, C.sub.1-6 alkyl or benzyl or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or hexahydroazepino ring;or a physiologically acceptable salt thereof, in the manufacture of a medicament for the treatment of a condition where a 5-HT.sub.1 -like agonist is indicated, for example migraine. Novel compounds of formula (I), processes for preparing them and pharmaceutical compositions containing them are also described.
公开/授权文献
- US4755857A Heterostructure semiconductor device 公开/授权日:1988-07-05