发明授权
- 专利标题： Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors
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申请号： US485826申请日： 1995-06-06
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公开(公告)号： US5646165A公开(公告)日： 1997-07-08
- 发明人: Matthew M. Abelman , Robert J. Ardecky , Ruth F. Nutt
- 申请人： Matthew M. Abelman , Robert J. Ardecky , Ruth F. Nutt
- 申请人地址： CA San Diego
- 专利权人： Corvas International, Inc.
- 当前专利权人： Corvas International, Inc.
- 当前专利权人地址： CA San Diego
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P7/02 ; C07K5/06 ; C07K5/062 ; C07K5/072 ; C07K5/078 ; A61K31/445 ; C07D295/03
摘要：
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.