发明授权
- 专利标题: Piperidine compounds
- 专利标题(中): 哌啶化合物
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申请号: US546263申请日: 1995-10-20
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公开(公告)号: US5652246A公开(公告)日: 1997-07-29
- 发明人: Guillaume de Nanteuil , Georges Remond , Bernard Portevin , Jacqueline Bonnet , Emmanuel Canet , Graham Birrell
- 申请人: Guillaume de Nanteuil , Georges Remond , Bernard Portevin , Jacqueline Bonnet , Emmanuel Canet , Graham Birrell
- 申请人地址: FRX Courbevoie
- 专利权人: Adir et Compagnie
- 当前专利权人: Adir et Compagnie
- 当前专利权人地址: FRX Courbevoie
- 优先权: FRX9412580 19941021
- 主分类号: A61K31/4427
- IPC分类号: A61K31/4427 ; A61K31/445 ; A61P1/00 ; A61P11/00 ; A61P13/02 ; A61P15/00 ; A61P25/00 ; A61P25/04 ; A61P25/06 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07D401/06 ; C07D471/04 ; C07D471/02 ; A61K31/415 ; A61K31/44 ; C07D235/22
摘要:
The invention relates to the compounds of formula (I): ##STR1## in which: R.sub.1 represents alkyl, phenyl, naphthyl, pyridyl or thienyl group, each phenyl, naphthyl, pyridyl or thienyl optionally being substituted,R.sub.2 represents a hydrogen atom or a substituted or unsubstituted alkyl, substituted or unsubstituted phenyl, cycloalkyl, piperidino or substituted or unsubstituted amino group,X represents CO or SO.sub.2,R.sub.3 represents hydrogen or alkyl,R.sub.4 represents alkyl, substituted or unsubstituted phenyl or trihalomethyl, or else R.sub.3 and R.sub.4 form, together with the carbon atoms which carry them, cyclo(C.sub.3 -C.sub.7)alkenyl,A represents phenyl, naphthyl or pyridyl ring, each phenyl, naphthyl or pyridyl ring optionally being substituted,their isomers, the corresponding quaternary ammonium salts of the piperidine and their addition salts with a pharmaceutically acceptable acid, an medicinal products containing the same are useful as antagonists of NK.sub.1 receptors.
公开/授权文献
- US5082404A Vehicle cargo clamp 公开/授权日:1992-01-21