Invention Grant
- Patent Title: Imidazole derivatives and processes for the preparation thereof
- Patent Title (中): 咪唑衍生物及其制备方法
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Application No.: US737563Application Date: 1996-11-13
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Publication No.: US5665738APublication Date: 1997-09-09
- Inventor: Sung-Eun Yoo , Kyu-Yang Yi , Sang-Hee Lee , Hye-Ryung Kim , Jee-Hee Suh , Nak-Jeong Kim , Seon-Ju Kim , Ok-Ja Cha , Young-Ah Shin , Wha-Sup Shin , Sung-Hou Lee , Yi-Sook Jung , Byung-Ho Lee , Ho-Won Seo , Hye-Suk Lee
- Applicant: Sung-Eun Yoo , Kyu-Yang Yi , Sang-Hee Lee , Hye-Ryung Kim , Jee-Hee Suh , Nak-Jeong Kim , Seon-Ju Kim , Ok-Ja Cha , Young-Ah Shin , Wha-Sup Shin , Sung-Hou Lee , Yi-Sook Jung , Byung-Ho Lee , Ho-Won Seo , Hye-Suk Lee
- Applicant Address: KRX Daejeon
- Assignee: Korea Research Institute of Chemical Technology
- Current Assignee: Korea Research Institute of Chemical Technology
- Current Assignee Address: KRX Daejeon
- Priority: KRX94-11099 19940521
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/4427 ; A61P9/12 ; A61P43/00 ; C07D401/14 ; A61K31/415 ; C07D403/14
Abstract:
Novel imidazole derivatives of formula(I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity: ##STR1## wherein: A is a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl group, or OR.sub.1 wherein R.sub.1 is a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical; B is a halogen, CF.sub.3 or CF.sub.2 CF.sub.3 ; X is N or N-oxide; Y is --CH.sub.2 --, --CH(OR.sub.1)-- wherein R.sub.1 is the same as defined above, or --C(.dbd.O)--; n is 0 or an integer of 1 to 4; Z is a halogen, --OH, --OR.sub.1, --NR.sub.1 R.sub.2, --N(.dbd.O)R.sub.3 R.sub.4, --C(.dbd.O)R.sub.1, --C(.dbd.O)OR.sub.1, --CH(OR.sub.1).sub.2 or --C(.dbd.O)N.sub.1 N.sub.2 wherein R.sub.1 is the same as defined above, R.sub.2 is, independently of R.sub.1, a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical, and R.sub.3 and R.sub.4 are independently a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical; and D is a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical.
Public/Granted literature
- US5151014A Lightweight airfoil Public/Granted day:1992-09-29
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