发明授权
- 专利标题： Trisubstituted benzene derivatives, composition and methods of treatment
- 专利标题（中）： 三取代苯衍生物，组成及处理方法
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申请号： US757908申请日： 1991-09-11
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公开(公告)号： US5668136A公开(公告)日： 1997-09-16
- 发明人: Teiji Kimura , Nobuhisa Watanabe , Yasutaka Takase , Kenji Hayashi , Makoto Matsui , Hironori Ikuta , Youji Yamagishi , Kozo Akasaka , Hiroshi Tanaka , Issei Ohtsuka , Takao Saeki , Motoji Kogushi , Tohru Fujimori , Isao Saito
- 申请人： Teiji Kimura , Nobuhisa Watanabe , Yasutaka Takase , Kenji Hayashi , Makoto Matsui , Hironori Ikuta , Youji Yamagishi , Kozo Akasaka , Hiroshi Tanaka , Issei Ohtsuka , Takao Saeki , Motoji Kogushi , Tohru Fujimori , Isao Saito
- 申请人地址： JPX Tokyo
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX2-251897 19900925; JPX3-091477 19910329
- 主分类号： A61K31/135
- IPC分类号： A61K31/135 ; A61K31/165 ; A61K31/17 ; A61K31/18 ; A61K31/27 ; A61K31/275 ; A61K31/415 ; A61K31/505 ; A61P3/06 ; A61P9/10 ; C07C233/18 ; C07C255/58 ; C07C255/59 ; C07C255/60 ; C07C275/34 ; C07C275/40 ; C07D211/14 ; C07D213/02 ; C07D233/54 ; C07D233/60 ; C07D233/68 ; C07D233/90 ; C07D233/96 ; C07D235/02 ; C07D235/06 ; C07D235/12 ; C07D235/14 ; C07D249/04 ; C07D249/06 ; C07D249/18 ; C07D253/08 ; C07D257/04 ; C07D295/08 ; C07D295/092 ; C07D401/04 ; C07D401/12 ; C07D403/12 ; C07D521/00 ; A61K31/495 ; C07D241/04
摘要：
A benzene, pyridine or pyrimidine derivative having the below shown formula is novel and useful as an anti-arteriosclerotic agent. ##STR1## wherein R.sup.1 stands for a lower alkyl group, an amino group which may be substituted, or the like; R.sup.2 stands for a group represented by the formula: ##STR2## (wherein R.sup.16 stands for an alkyl group having 1 to 6 carbon atoms, or the like) or the like; R.sup.3 stands for a group represented by the formula: --O--(CH.sub.2).sub.m --Y (Y stands for an imidazolyl or piperazinyl group, or the like and m is 1 to 6) or the like; R.sup.5 stands for a hydrogen atom, a lower alkyl group, or the like; A stands for a group represented by the formula: ##STR3## (wherein R.sup.6 stands for a hydrogen atom, a lower alkyl group, or the like), --N.dbd., or the like; and B stands for a group represented by the formula: ##STR4## (wherein R.sup.4 stands for a hydrogen or the like), --N.dbd., or the like.