发明授权
US5670338A DNA encoding bone morphogenetic proteins, host cells transformed there
by, and uses thereof
失效
编码骨形态发生蛋白的DNA，在其中转化的宿主细胞及其用途
- 专利标题： DNA encoding bone morphogenetic proteins, host cells transformed there by, and uses thereof
- 专利标题（中）： 编码骨形态发生蛋白的DNA，在其中转化的宿主细胞及其用途
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申请号： US455550申请日： 1995-05-31
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公开(公告)号： US5670338A公开(公告)日： 1997-09-23
- 发明人: Kazuo Murakami , Naoto Ueno , Yukio Kato
- 申请人： Kazuo Murakami , Naoto Ueno , Yukio Kato
- 申请人地址： JPX Osaka JPX Tokyo
- 专利权人： Takeda Chem. Ind. Ltd.,Chichibu Onoda Cement Corp.
- 当前专利权人： Takeda Chem. Ind. Ltd.,Chichibu Onoda Cement Corp.
- 当前专利权人地址： JPX Osaka JPX Tokyo
- 优先权： JPX1-229250 19890906; JPX2-190774 19900720
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; A61P3/02 ; A61P19/10 ; A61P43/00 ; C07K14/00 ; C07K14/51 ; C12N1/21 ; C12N15/12 ; C12N15/16 ; C12P21/02 ; C12R1/19 ; C12R1/91 ; C12N15/00
摘要：
Disclosed are (1) a Xenopus laevis bone morphogenetic protein (BMP), (2) a DNA comprising a DNA segment coding for a Xenopus laevis BMP, (3) a transformant bearing a DNA comprising a DNA segment coding for a Xenopus laevis BMP and (4) a method for preparing the Xenopus laevis BMP which comprises culturing the described in (3), producing and accumulating the protein in a culture, and collecting the protein thus obtained. Cells transinfected or transformed with the DNA allow large amounts of the Xenopus laevis BMP mature peptides to be produced, which causes the advantageous production of the peptides, which promote the synthesis of proteoglycan and can also be utilized for analysis of the mechanism of organism, particularly human bone-cartilage morphogenetic reaction, and as therapeutic agents for osteoporosis.
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