发明授权
- 专利标题： Methods for enhanced retrovirus-mediated gene transfer
- 专利标题（中）： 增强逆转录病毒介导基因转移的方法
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申请号： US218355申请日： 1994-03-25
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公开(公告)号： US5686278A公开(公告)日： 1997-11-11
- 发明人: David A. Williams , Vikram P. Patel
- 申请人： David A. Williams , Vikram P. Patel
- 申请人地址： IN Bloomington
- 专利权人： Indiana University Foundation
- 当前专利权人： Indiana University Foundation
- 当前专利权人地址： IN Bloomington
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A01K67/027 ; A61K35/28 ; A61K35/76 ; A61K38/00 ; A61K38/04 ; A61K38/16 ; A61K38/22 ; A61K38/27 ; A61K38/46 ; A61K39/395 ; A61K47/48 ; A61K48/00 ; A61P7/00 ; A61P35/00 ; A61P43/00 ; C07H21/04 ; C07J1/00 ; C07K14/435 ; C07K14/47 ; C07K14/78 ; C07K17/14 ; C07K19/00 ; C12M3/00 ; C12N5/10 ; C12N9/78 ; C12N15/48 ; C12N15/63 ; C12N15/867
摘要：
A method to increase the efficiency of transduction of hematopoietic cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The fibronectin and fibronectin fragments significantly enhance retroviral-mediated gene transfer into the hematopoietic cells, particularly including committed progenitors and primitive hematopoietic stem cells. The invention also provides improved methods for somatic gene therapy capitalizing on the enhanced gene transfer, and hematopoietic cellular populations.
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