发明授权
US5700937A Method for the synthesis, compositions and use of
2'-deoxy-5-fluoro-3'-thiacytidine and related compounds
失效
2'-脱氧-5-氟-3'-硫代胞苷及其相关化合物的合成，组合和用途的方法
- 专利标题： Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds
- 专利标题（中）： 2'-脱氧-5-氟-3'-硫代胞苷及其相关化合物的合成，组合和用途的方法
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申请号： US481556申请日： 1995-06-07
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公开(公告)号： US5700937A公开(公告)日： 1997-12-23
- 发明人: Dennis C. Liotta , Raymond F. Schinazi , Woo-Baeg Choi
- 申请人： Dennis C. Liotta , Raymond F. Schinazi , Woo-Baeg Choi
- 申请人地址： GA Atlanta
- 专利权人： Emory University
- 当前专利权人： Emory University
- 当前专利权人地址： GA Atlanta
- 主分类号： C07D327/04
- IPC分类号： C07D327/04 ; C07D405/04 ; C07D411/04 ; C07H19/00 ; C07H19/06 ; C07H19/10 ; A61K31/505 ; A61K9/127
摘要：
The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevention and treatment of AIDS; and the compounds themselves. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds and related compounds.
公开/授权文献
- US5079657A Textured air bearing surface 公开/授权日：1992-01-07
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