An endoscope includes an operating portion placed outside a living body, an insertion portion having a proximal end portion coupled to the operating portion, a distal end portion inserted in the living body, and an instrument insertion channel extending through the insertion portion, a raising mechanism having an operation wire and designed to direct the distal end portion of an instrument, caused to extend through the channel, to a predetermined position, and an operation means for operating the operation wire. The endoscope includes a distal end body portion arranged at the distal end portion of the insertion portion and incorporating an observation means for observing the interior of the living body, a support member for forming at least a portion of the outer surface of the distal end portion. The support member is detachable from the distal end body portion. The endoscope further includes a raising base which is supported on the support member such that the angle at which the raising base is arranged can be adjusted. The angle of the raising base is adjusted by the operation wire. The operation wire is detachable from the operation means.