发明授权
US5731350A Substituted benzenedicarboxylic acid diguanides, process for their
preparation, their use as a medicament or diagnostic, and medicament
containing them
失效
取代的苯二甲酸二环酮，其制备方法，它们作为药物或诊断剂的用途，以及含有它们的药物
- 专利标题： Substituted benzenedicarboxylic acid diguanides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
- 专利标题（中）： 取代的苯二甲酸二环酮，其制备方法，它们作为药物或诊断剂的用途，以及含有它们的药物
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申请号： US747004申请日： 1996-11-07
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公开(公告)号： US5731350A公开(公告)日： 1998-03-24
- 发明人: Heinz-Werner Kleemann , Joachim Brendel , Jan-Robert Schwark , Andreas Weichert , Hans Jochen Lang , Udo Albus , Wolfgang Scholz
- 申请人： Heinz-Werner Kleemann , Joachim Brendel , Jan-Robert Schwark , Andreas Weichert , Hans Jochen Lang , Udo Albus , Wolfgang Scholz
- 申请人地址： DEX Frankfurt am Main
- 专利权人： Hoechst Aktiengesellschaft
- 当前专利权人： Hoechst Aktiengesellschaft
- 当前专利权人地址： DEX Frankfurt am Main
- 优先权： DEX19543194.4 19951120; DEX19626327.1 19960701
- 主分类号： A61K31/165
- IPC分类号： A61K31/165 ; A61P1/16 ; A61P3/08 ; A61P9/08 ; A61P9/10 ; A61P11/00 ; A61P13/02 ; A61P15/00 ; A61P35/00 ; A61P43/00 ; C07C279/20 ; C07C279/22 ; A61K31/16 ; C07C233/67
摘要：
Benzenedicarboxylic acid diguanides of the formula I ##STR1## in which R(1) to R(5) have the meanings given in the claims, are useful antiarrhythmic pharmaceuticals having a cardioprotective component, even for the prevention of ischemically induced damage, in particular in the induction of ischemically induced cardiac arrhythmias. As a result of inhibition of the cellular Na.sup.+ /H.sup.+ exchange mechanism, they are used for the treatment of acute or chronic damage caused by ischemia. Moreover, they are distinguished by potent inhibitory action on the proliferation of cells. They are suitable for preventing the genesis of high blood pressure.
公开/授权文献
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