发明授权
US5736336A Peptide nucleic acids having enhanced binding affinity, sequence
specificity and solubility
失效
具有增强的结合亲和力，序列特异性和溶解度的肽核酸
- 专利标题： Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
- 专利标题（中）： 具有增强的结合亲和力，序列特异性和溶解度的肽核酸
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申请号： US847108申请日： 1997-05-01
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公开(公告)号： US5736336A公开(公告)日： 1998-04-07
- 发明人: Ole Buchardt, deceased , by Dorte Buchardt, representative , Michael Egholm , Peter Eigil Nielsen , Rolf Henrik Berg
- 申请人： Ole Buchardt, deceased , by Dorte Buchardt, representative , Michael Egholm , Peter Eigil Nielsen , Rolf Henrik Berg
- 专利权人： Buchardt, Deceased; Ole,Buchardt, Representative; By Dorte,Egholm; Michael,Nielsen; Peter Eigil,Berg; Rolf Henrik
- 当前专利权人： Buchardt, Deceased; Ole,Buchardt, Representative; By Dorte,Egholm; Michael,Nielsen; Peter Eigil,Berg; Rolf Henrik
- 优先权： DKXDK0986/91 19910524; DKXDK0987/91 19910524; DKXDK0510/92 19920415
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07H21/00 ; C07K5/06 ; C07K5/078 ; C07K7/06 ; C07K7/08 ; C07K14/00 ; C12Q1/68 ; C07K5/00
摘要：
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C.sub.1 -C.sub.8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided.
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