发明授权
US5739120A Treatment of viral infections by administration of
.alpha.-�1-(3-alkylthio-3-deoxy-2-O-acylglyceryl)!-.omega.�5'-(9-arabino
sylpurinyl)! diphosphates or purine isosters thereof
失效
通过给予α-[1-（3-烷硫基-3-脱氧-2-O-酰基甘油基）] - ω[5' - （9-阿糖基ur啶基）]二磷酸酯或其嘌呤等价物来治疗病毒感染
- 专利标题： Treatment of viral infections by administration of .alpha.-�1-(3-alkylthio-3-deoxy-2-O-acylglyceryl)!-.omega.�5'-(9-arabino sylpurinyl)! diphosphates or purine isosters thereof
- 专利标题（中）： 通过给予α-[1-（3-烷硫基-3-脱氧-2-O-酰基甘油基）] - ω[5' - （9-阿糖基ur啶基）]二磷酸酯或其嘌呤等价物来治疗病毒感染
-
申请号： US837275申请日： 1997-04-30
-
公开(公告)号： US5739120A公开(公告)日： 1998-04-14
- 发明人: Woo Hyun Paik , Won Sup Shin , Jae Seung Lee , Hee Sang Chai
- 申请人： Woo Hyun Paik , Won Sup Shin , Jae Seung Lee , Hee Sang Chai
- 申请人地址： KRX Seoul
- 专利权人： Boryung Pharmaceutical Co., Ltd.
- 当前专利权人： Boryung Pharmaceutical Co., Ltd.
- 当前专利权人地址： KRX Seoul
- 优先权： KRX93-26496 19931204
- 主分类号： C07H19/14
- IPC分类号： C07H19/14 ; A61K9/08 ; A61K9/48 ; A61K31/70 ; A61K31/7042 ; A61K31/7052 ; A61K31/7064 ; A61K31/7076 ; A61P31/12 ; C07H19/20
摘要：
The present invention relates to new liponucleotide analog compounds having useful antiviral activity, represented by general formula (I): ##STR1## wherein R.sup.1 is a saturated or unsaturated alkyl having 6-22 C atoms; R.sup.2 is a saturated or unsaturated alkyl having 12-20 C atoms; R.sup.3 and R.sup.4 are each hydrogen or hydroxy; and B is one of the nucleoside bases of formula (a): ##STR2## wherein R.sup.5 is a hydrogen, halogen, hydroxy, amino, mercapto, or C.sub.1 -C.sub.4 alkyl amino; R.sup.6 is a hydrogen, halogen or amino; W is a nitrogen or C--R.sup.8 where R.sup.8 is hydrogen, halogen, amino or C.sub.1 -C.sub.4 alkyl, and pharmaceutically acceptable salts thereof.
公开/授权文献
- US4784127A Device for fixing the fractured ends of a bone 公开/授权日：1988-11-15
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