公开(公告)号：US5739120A

公开(公告)日：1998-04-14

申请号：US837275

申请日：1997-04-30

申请人： Woo Hyun Paik ,  Won Sup Shin ,  Jae Seung Lee ,  Hee Sang Chai

发明人： Woo Hyun Paik ,  Won Sup Shin ,  Jae Seung Lee ,  Hee Sang Chai

IPC分类号： C07H19/14 ,  A61K9/08 ,  A61K9/48 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7076 ,  A61P31/12 ,  C07H19/20

CPC分类号： C07H19/20

摘要： The present invention relates to new liponucleotide analog compounds having useful antiviral activity, represented by general formula (I): ##STR1## wherein R.sup.1 is a saturated or unsaturated alkyl having 6-22 C atoms; R.sup.2 is a saturated or unsaturated alkyl having 12-20 C atoms; R.sup.3 and R.sup.4 are each hydrogen or hydroxy; and B is one of the nucleoside bases of formula (a): ##STR2## wherein R.sup.5 is a hydrogen, halogen, hydroxy, amino, mercapto, or C.sub.1 -C.sub.4 alkyl amino; R.sup.6 is a hydrogen, halogen or amino; W is a nitrogen or C--R.sup.8 where R.sup.8 is hydrogen, halogen, amino or C.sub.1 -C.sub.4 alkyl, and pharmaceutically acceptable salts thereof.

摘要翻译： 本发明涉及由通式（I）表示的具有有效抗病毒活性的新的脂类核苷酸类似物化合物：其中R 1是具有6-22个C原子的饱和或不饱和烷基; R2是具有12-20个C原子的饱和或不饱和的烷基; R3和R4各自为氢或羟基; B是式（a）的核苷碱之一：其中R5是氢，卤素，羟基，氨基，巯基或C1-C4烷基氨基; R6是氢，卤素或氨基; W是氮或C-R8，其中R8是氢，卤素，氨基或C1-C4烷基，及其药学上可接受的盐。