发明授权
- 专利标题: Bone augmentation material
- 专利标题(中): 骨增强材料
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申请号: US631818申请日: 1996-04-10
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公开(公告)号: US5739286A公开(公告)日: 1998-04-14
- 发明人: Frederick H. Silver , David Christiansen
- 申请人: Frederick H. Silver , David Christiansen
- 专利权人: Silver; Frederick H.,Christiansen; David
- 当前专利权人: Silver; Frederick H.,Christiansen; David
- 主分类号: A61F2/00
- IPC分类号: A61F2/00 ; A61K38/00 ; A61L27/24 ; A61L27/46 ; C07K14/78 ; A61K37/12 ; C07K14/00 ; C08H1/06 ; C08L89/00
摘要:
There is disclosed a process for the mineralization of collagen fibers whereby collagen fibers formed from collagen are contacted with a solution of calcium and phosphate ions under conditions to effect nucleation and in-vitro growth of mineral crystals within and on the surface of the collagen fibers to form intact collagen fibers with subfibrillar substructure and wherein preparations of such mineralized collagen fibers are used in bone replacement therapy as well as to induce repair in bony defects.