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公开(公告)号：US5739286A
公开(公告)日：1998-04-14
申请号：US631818
申请日：1996-04-10
IPC分类号： A61F2/00 , A61K38/00 , A61L27/24 , A61L27/46 , C07K14/78 , A61K37/12 , C07K14/00 , C08H1/06 , C08L89/00
CPC分类号： A61L27/46 , A61L27/24 , C07K14/78 , A61F2310/00365 , A61K38/00
摘要： There is disclosed a process for the mineralization of collagen fibers whereby collagen fibers formed from collagen are contacted with a solution of calcium and phosphate ions under conditions to effect nucleation and in-vitro growth of mineral crystals within and on the surface of the collagen fibers to form intact collagen fibers with subfibrillar substructure and wherein preparations of such mineralized collagen fibers are used in bone replacement therapy as well as to induce repair in bony defects.
摘要翻译： 公开了一种胶原纤维矿化的方法，其中由胶原纤维形成的胶原纤维与钙和磷酸根离子的溶液接触，以使胶原纤维内部和表面上的矿物晶体成核和体外生长， 形成具有亚原纤维下结构的完整胶原纤维，并且其中将这种矿化胶原纤维的制剂用于骨替代疗法以及诱导骨缺损修复。
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2.发明授权Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone 失效胶原纤维矿化的方法，由此生产的产品及其用于修复骨的方法
公开(公告)号：US5532217A
公开(公告)日：1996-07-02
申请号：US524752
申请日：1995-09-07
IPC分类号： A61F2/00 , A61K38/00 , A61L27/24 , A61L27/46 , C07K14/78 , A61K38/17 , C07K14/00 , C08H1/06 , C08L89/00
CPC分类号： A61L27/46 , A61L27/24 , C07K14/78 , A61F2310/00365 , A61K38/00
摘要： There is disclosed a process for the mineralization of collagen fibers whereby collagen fibers formed from collagen are contacted with a solution of calcium and phosphate ions under conditions to effect nucleation and in-vitro growth of mineral crystals within and on the surface of the collagen fibers to form intact collagen fibers with subfibrillar substructure and wherein preparations of such mineralized collagen fibers are used in bone replacement therapy as well as to induce repair in bony defects.
摘要翻译： 公开了一种胶原纤维矿化的方法，其中由胶原纤维形成的胶原纤维与钙和磷酸根离子的溶液接触，以使胶原纤维内部和表面上的矿物晶体成核和体外生长， 形成具有亚原纤维下结构的完整胶原纤维，并且其中将这种矿化胶原纤维的制剂用于骨替代疗法以及诱导骨缺损修复。
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公开(公告)号：US4280954A
公开(公告)日：1981-07-28
申请号：US30183
申请日：1979-04-16
CPC分类号： C08H1/00 , A23J1/10 , A61L17/10 , A61L27/24 , A61L27/26 , C08B37/0063 , A61F2310/00365
摘要： Composite materials are disclosed which are formed by contacting collagen with a mucopolysaccharide and subsequently covalently crosslinking the resultant polymer. These composite materials have a balance of mechanical, chemical and physiological properties which make them useful in surgical sutures and prostheses of controlled biodegradability (resorption) and controlled ability to prevent development of a foreign body reaction, and many are also useful in applications in which blood compatibility is required.
摘要翻译： 公开了通过使胶原与粘多糖接触并随后共价交联所得聚合物而形成的复合材料。 这些复合材料具有机械，化学和生理特性的平衡，使得它们可用于可控生物降解性（吸收）的手术缝线和假体以及防止异物反应发展的受控能力，并且许多也可用于血液 需要兼容性。
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4.发明授权Synthetic collagen orthopaedic structures such as grafts, tendons and other structures 失效合成胶原骨架结构如移植物，腱和其他结构
公开(公告)号：US5171273A
公开(公告)日：1992-12-15
申请号：US297115
申请日：1989-01-13
CPC分类号： A61L27/24 , A61L27/48 , A61F2/08 , A61F2310/00365
摘要： The invention provides graft, prothesis, orthopaedic structures, implants and like body replacement parts which are constituted of synthetic collagen fibers, an embodiment of which is a tendon or a ligament prosthesis, graft or implants. These body parts have a combination of very useful properties, particularly high tensile strength combined with biocompatability.
摘要翻译： 本发明提供由合成胶原纤维构成的移植物，假体，矫形结构，植入物和类似的身体替换部件，其一个实施例是腱或韧带假体，移植物或植入物。 这些身体部位具有非常有用的特性，特别是高抗拉强度与生物相容性的组合。
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公开(公告)号：US4970298A
公开(公告)日：1990-11-13
申请号：US875827
申请日：1986-06-18
IPC分类号： A01N25/10 , A61F2/10 , A61F13/00 , A61K20060101 , A61K9/00 , A61K9/22 , A61K9/70 , A61K47/00 , A61L20060101 , A61L15/00 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , A61L17/00 , A61L26/00 , A61L27/24 , A61L27/56 , A61L27/58 , C08H20060101 , C08H1/00 , C08L89/00 , C08L89/06 , C09H1/00
CPC分类号： A61L15/425 , A61K9/70 , A61L15/325 , A61L15/44 , A61L15/64 , A61L26/0033 , A61L27/24 , A61L27/56 , A61L27/58 , C08L89/06 , A61L2300/232 , A61L2300/252 , A61L2300/254 , A61L2300/404 , A61L2300/412 , A61L2300/414 , A61L2300/434 , Y10S128/08 , Y10S514/801
摘要： This invention relates to a biodegradable collagen matrix having a pore size and morphology which enhances the healing of a wound. It further relates to a process for preparing the matrix. One embodiment of the invention comprises a biodegradable matrix which comprises collagen, hyaluronic acid and fibronectin. Other embodiments include a process which comprises freeze drying a dispersion containing collagen, crosslinking the collagen via two crosslinking steps and freeze drying the crosslinked matrix.
摘要翻译： 本发明涉及具有增加伤口愈合的孔径和形态的可生物降解的胶原基质。 它还涉及一种制备该基质的方法。 本发明的一个实施方案包括可生物降解的基质，其包含胶原，透明质酸和纤连蛋白。 其它实施方案包括冷冻干燥含有胶原的分散体，通过两个交联步骤交联胶原蛋白并冷冻干燥交联的基质的方法。
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公开(公告)号：US4997753A
公开(公告)日：1991-03-05
申请号：US393656
申请日：1989-08-14
申请人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr.
发明人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr.
CPC分类号： C12N11/02 , C12N1/00 , C12N5/0075 , C12P1/00 , C12N2533/54
摘要： Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05.
摘要翻译： 描述了具有高度交联的胶原基质的加重胶原微球适用于在动力反应器系统中培养生物体。 微球具有开放的表面孔结构，并且适合于固定各种生物活性材料的孔径和体积。 微球也具有约100至约1000微米范围内的平均粒度和约1.05以上的比重。
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公开(公告)号：US4863856A
公开(公告)日：1989-09-05
申请号：US932088
申请日：1986-11-18
申请人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr. , Gennaro J. Maffia
发明人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr. , Gennaro J. Maffia
CPC分类号： C12N1/00 , C12N11/02 , C12N5/0075 , C12P1/00 , C12N2533/54
摘要： Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05.
摘要翻译： 描述了具有高度交联的胶原基质的加重胶原微球适用于在动力反应器系统中培养生物体。 微球具有开放的表面孔结构，并且适合于固定各种生物活性材料的孔径和体积。 微球也具有约100至约1000微米范围内的平均粒度和约1.05以上的比重。
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公开(公告)号：US4861714A
公开(公告)日：1989-08-29
申请号：US719881
申请日：1985-04-04
申请人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr.
发明人： Robert C. Dean, Jr. , Frederick H. Silver , Richard A. Berg , Philip G. Phillips , Peter W. Runstadler, Jr.
CPC分类号： C12P1/00 , C12N1/00 , C12N11/02 , C12N5/0075 , C12N2533/54
摘要： Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the surface pore structure, and pore sizes and volumes suitable for immobilizing a variety of bioactive materials. The microsponges also have an average particle size in the range of about 100 to about 1000 microns and a specific gravity above about 1.05.
摘要翻译： 描述了具有高度交联的胶原基质的加重胶原微球适用于在动力反应器系统中培养生物体。 微球具有开放的表面孔结构，并且适合于固定各种生物活性材料的孔径和体积。 微球也具有约100至约1000微米范围内的平均粒度和约1.05以上的比重。
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公开(公告)号：US4837285A
公开(公告)日：1989-06-06
申请号：US93826
申请日：1987-09-08
IPC分类号： A61K9/70 , A61L15/32 , A61L15/44 , A61L15/64 , A61L27/24 , A61L27/56 , A61L27/58 , C08L89/06
CPC分类号： C08L89/06 , A61K9/70 , A61L15/325 , A61L15/44 , A61L15/64 , A61L27/24 , A61L27/56 , A61L27/58 , A61L2300/232 , A61L2300/252 , A61L2300/412 , Y10S128/08
摘要： Collagen-based compositions for augmenting soft tissue, wound dressings, implants, injectable formulations or other drug delivery systems, comprising resorbable collagen matrix beads, the beads having an average pore size of from 50 to 350 microns, and the collagen comprising from 1 to 30% by volume of the beads, the collagen matrix being sufficiently open to stimulate cellular ingrowth therethrough and yet sufficiently stiff and non-compressible to fill and protect a wound, and the formulation being sufficiently moisture and gas permeable to prevent liquid pooling on a wound and to permit sufficient oxygen diffusion for promoting wound healing.
摘要翻译： 用于增加软组织，伤口敷料，植入物，可注射制剂或其它药物递送系统的基于胶原的组合物，其包含可再吸收的胶原基质珠粒，所述珠粒的平均孔径为50至350微米，所述胶原蛋白包含1至30 体积的珠子，胶原基质足够开放以刺激细胞向内生长并且足够坚硬和不可压缩以填充和保护伤口，并且制剂具有足够的水分和气体可渗透性以防止液体汇集在伤口上， 以允许足够的氧气扩散以促进伤口愈合。
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10.发明授权Process and apparatus for harvesting tissue for processing tissue and process and apparatus for re-injecting processed tissue 失效用于收集用于加工组织的组织的方法和装置以及用于再注射经处理的组织的方法和装置
公开(公告)号：US5827217A
公开(公告)日：1998-10-27
申请号：US708307
申请日：1996-09-04
CPC分类号： A61L27/3683 , A61B17/1637 , A61F2/4601 , A61B10/0233 , A61B2017/0046 , A61B2017/00969 , A61F2002/4635 , A61F2002/4649
摘要： There is disclosed a method and apparatus for harvesting tissue using a cannula having a diameter of from 0.5 to 4.0 mm and of a length of from 25 to 20 cm to access by minimally invasive techniques a host to withdraw autogenous tissue processed to remove loose fat and/or fragmented tissue. Thereafter, the resulting tissue substrate is morcellated to form particulate tissue of a particle size of from 1 to 200 .mu.m. The particulate material is thence passed through screens having opening sizes of from 1 to 100 .mu.m to form a material of a size for introduction into a syringe of from 16 to 30 gauge for implantation in the host. The processed tissue may be admixed with extenders, gelling agents and the like.
摘要翻译： 公开了一种使用直径为0.5至4.0mm且长度为25至20cm的套管收集组织的方法和装置，以通过微创技术获得主机以撤回被处理以除去松散脂肪的自体组织， /或碎片组织。 然后，将得到的组织基板脱模，形成粒径为1〜200μm的微粒组织。 然后将颗粒材料通过具有1至100μm的开口尺寸的筛网，以形成用于引入到注射器中的尺寸为16至30的尺寸的材料，用于植入宿主体内。 经加工的组织可以与增量剂，胶凝剂等混合。
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