发明授权
- 专利标题： Recombinant disulfide-stabilized polypeptide fragments having binding specificity
-
申请号： US77252申请日： 1993-06-14
-
公开(公告)号： US5747654A公开(公告)日： 1998-05-05
- 发明人: Ira H. Pastan , Byungkook Lee , Sun-Hee Jung , Ulrich Brinkmann
- 申请人： Ira H. Pastan , Byungkook Lee , Sun-Hee Jung , Ulrich Brinkmann
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： C12N15/02
- IPC分类号： C12N15/02 ; A61K38/00 ; A61K39/395 ; A61K47/48 ; A61P35/00 ; C07K14/725 ; C07K16/00 ; C07K17/00 ; C12N15/09 ; C12P21/08 ; C07K19/00 ; C07K16/46
摘要：
The present invention relates to disulfide-stabilized recombinant polypeptide molecules which have the binding ability and specificity for another peptide, such as the variable region of an antibody molecule. Methods of producing these molecules and nucleic acid sequences encoding these molecules are also described. In particular, the invention discloses Fv antibody fragments stabilized by a disulfide bond connecting the V.sub.H and V.sub.L regions of the Fv fragment. The .alpha. and .beta. chains of T cell receptors may be similarly stabilized by means described in the invention.
公开/授权文献
- US4811124A Defect skipping mechanism for disk drives 公开/授权日：1989-03-07
信息查询
IPC分类:
