- 专利标题: Methods and compositions for secretion of heterologous polypeptides
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申请号: US398617申请日: 1995-03-01
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公开(公告)号: US5747662A公开(公告)日: 1998-05-05
- 发明人: Laura C. Simmons , Daniel G. Yansura
- 申请人: Laura C. Simmons , Daniel G. Yansura
- 申请人地址: CA S. San Francisco
- 专利权人: Genentech, Inc.
- 当前专利权人: Genentech, Inc.
- 当前专利权人地址: CA S. San Francisco
- 主分类号: C07K14/245
- IPC分类号: C07K14/245 ; C12N15/70 ; C07H21/04
摘要:
The instant invention discloses the unexpected result that mutant signal sequences with reduced translational strength provided essentially complete processing and high levels of expression of a polypeptide of interest as compared to wild type signal sequences, and that many mammalian polypeptides require a narrow range of translation levels to achieve maximum secretion. A set of signal sequence vectors provides a range of translational strengths for optimizing expression of a polypeptide of interest.
公开/授权文献
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