发明授权
US5750102A Double transfectants of the MHC genes as cellular vaccines for immuno
prevention of tumor metastasis
失效
MHC基因的双重转染子作为用于免疫预防肿瘤转移的细胞疫苗
- 专利标题： Double transfectants of the MHC genes as cellular vaccines for immuno prevention of tumor metastasis
- 专利标题（中）： MHC基因的双重转染子作为用于免疫预防肿瘤转移的细胞疫苗
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申请号： US412512申请日： 1995-03-29
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公开(公告)号： US5750102A公开(公告)日： 1998-05-12
- 发明人: Lea Eisenbach , Michael Feldman
- 申请人： Lea Eisenbach , Michael Feldman
- 申请人地址： ILX Rehovot
- 专利权人： Yeda Research and Development Co., Ltd.
- 当前专利权人： Yeda Research and Development Co., Ltd.
- 当前专利权人地址： ILX Rehovot
- 优先权： EPX92104382 19920313
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/385 ; A61K48/00 ; C07K14/74 ; C12N20060101 ; A61K35/12 ; C12N5/08 ; C12N15/06 ; C12N15/09
摘要：
The present invention relates to anti-tumor vaccines comprising at least one type of tumor cell into each of which at least two genes encoding MHC proteins of different haplotypes have been inserted, or naturally expressed, said genes being expressed in said tumor cells and wherein at least one of said MHC proteins has the same haplotype as a haplotype of the individual to be vaccinated. The invention furthermore relates to a method of treating a patient suffering from a tumorous disease comprising administering a vaccine of the invention and to the use of a vaccine of the invention for the preparation of an anti-tumor vaccine.
公开/授权文献
- US5022683A Check insert and envelope 公开/授权日：1991-06-11
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