发明授权
US5753660A Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide
retroviral protease inhibitors
失效
取代磺酰基烷酰氨基羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂
- 专利标题: Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
- 专利标题(中): 取代磺酰基烷酰氨基羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂
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申请号: US747357申请日: 1996-11-13
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公开(公告)号: US5753660A公开(公告)日: 1998-05-19
- 发明人: James A. Sikorski , Daniel P. Getman , Gary A. DeCrescenzo , Balekudru Devadas , John N. Freskos , Hwang-Fun Lu , Joseph J. McDonald
- 申请人: James A. Sikorski , Daniel P. Getman , Gary A. DeCrescenzo , Balekudru Devadas , John N. Freskos , Hwang-Fun Lu , Joseph J. McDonald
- 申请人地址: MO St. Louis
- 专利权人: G. D. Searle & Co.
- 当前专利权人: G. D. Searle & Co.
- 当前专利权人地址: MO St. Louis
- 主分类号: C07D249/18
- IPC分类号: C07D249/18 ; A61K31/336 ; A61K31/343 ; A61K31/357 ; A61K31/36 ; A61K31/381 ; A61K31/4025 ; A61K31/407 ; A61K31/4155 ; A61K31/4178 ; A61K31/4192 ; A61K31/4196 ; A61K31/428 ; A61K31/443 ; A61K31/497 ; A61K31/501 ; A61K31/506 ; A61K31/7024 ; A61P31/18 ; C07C311/29 ; C07C311/41 ; C07D235/12 ; C07D235/30 ; C07D235/32 ; C07D277/62 ; C07D277/64 ; C07D277/82 ; C07D303/36 ; C07D307/79 ; C07D317/62 ; C07D319/18 ; C07D405/12 ; C07D407/12 ; C07D409/12 ; C07D413/12 ; C07D417/12 ; C07D491/056 ; C07H13/00 ; A61K31/335
摘要:
Selected sulfonylalkanoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
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